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  • 1,3-Dibutyl-l-nitrosourea  (1)
  • Acute autonomic and sensory neuropathy  (1)
  • Aminoacidaemia  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Hyperamino-acidaemia and hyperammonaemia in epileptic children treated with valproic acid (1988)
    Springer
    European journal of pediatrics 148 (1988), S. 267-269 
    Details
    ISSN: 1432-1076
    Keywords: Valproic acid ; Hyperammonaemia ; Aminoacidaemia ; Mitochondrial dysfunction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum amino acid pattern, blood ammonia, and serum valproic acid (VPA) levels were estimated in 75 epileptic children with and without VPA therapy. The incidence of patients with hyperammonaemia (〉60 μmol/l) in patients treated with only VPA or with a combination of VPA and other antiepileptic drugs was 19% and 20% respectively. Hyperammonaemia was not observed in patients receiving other drugs. Elevated levels of serum glycine, alanine and serine were more common in epileptic patients treated with VPA alone and with VPA in combination with other drugs than in patients receiving other drugs. A significant positive correlation was found between the serum levels of glycine and alanine, of glycine and serine, and of serine and alanine. These findings may indicate a mitochondrial dysfunction caused by VPA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00441418
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mammary tumorigenic effect of a new nitrosourea, 1,3-dibutyl-l-nitrosourea (B-BNU), in female Donryu rats (1980)
    Springer
    Journal of cancer research and clinical oncology 96 (1980), S. 35-41 
    Details
    ISSN: 1432-1335
    Keywords: Mammary tumor ; Nitrosourea ; 1,3-Dibutyl-l-nitrosourea ; Donryu rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four groups (groups 1-4) of female Donryu rats were given continuously 400, 200, 100, or 0 ppm solution of 1,3-dibutyl-1-nitrosourea (B-BNU) as their drinking water, and were studied for the development of tumors. The incidence of mammary tumors was 15/19 (79%), 20/24 (83%), 21/26 (81%), and 8/25 (32%) in groups 1, 2, 3, and 4, respectively. In addition, hematopoietic neoplasms, uterine tumors, and vaginal tumors developed in 13, 11, and six rats, respectively in 69 treated rats. Other tumors were infrequent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00412895
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Acute autonomic and sensory neuropathy: a case report (1990)
    Springer
    Journal of neurology 237 (1990), S. 42-44 
    Details
    ISSN: 1432-1459
    Keywords: Acute autonomic and sensory neuropathy ; Epstein-Barr virus ; Orthostatic hypotension ; Peripheral neuropathy ; l-Threo-2,3.-dihydroxyphenylserine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A female patient with acute autonomic and sensory neuropathy is described. Urinary disturbance developed rapidly and was followed by orthostatic syncope, absence of lacrimation, salivation and sweating, and sensory impairment. Muscle strength had been consistently normal despite diffuse muscular atrophy. Marked decrease in the number of small myelinated and unmyelinated fibres was revealed in biopsied sural nerve. Eighteen months after the onset, her autonomic symptoms have partially improved.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319667
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    Paper (German National Licenses)
    Fulltext
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