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  • 1α-hydroxyvitamin D3  (1)
  • Tosufloxacin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Stereoselective analysis of the disposition of tosufloxacin enantiomers in man (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 489-491 
    Details
    ISSN: 1432-1041
    Keywords: Tosufloxacin ; Enantiomer ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of tosufloxacin enantiomers after oral administration of racemic tosufloxacin were examined in healthy volunteers. Only small differences were observed in time to peak concentration (2.6±0.3 [mean ± SEM] h for (+)-tosufloxacin vs 2.4±0.2 h for (−)-tosufloxacin), elimination half-life (3.61±0.24 h vs 3.49±0.23 h), and area under the curve (2.78±0.19 h·μg/ml vs 2.87±0.19 h·μg/ml); however, peak concentration (0.40±0.03 μg/ml vs 0.44±0.03 μg/ml), renal clearance (226±10 ml/min vs 202±10 ml/min), and urinary recovery (35.4±2.2% vs 32.4±1.9%) differed significantly between enantiomers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315523
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Vitamin D dependent rickets: Decreased sensitivity to 1,25-dihydroxyvitamin D (1981)
    Springer
    European journal of pediatrics 137 (1981), S. 307-311 
    Details
    ISSN: 1432-1076
    Keywords: Vitamin D dependent rickets ; 1α-hydroxyvitamin D3 ; Hypocalcemia ; Osteomalacia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A patient with vitamin D dependent rickets with decreased sensitivity to 1,25-Dihydroxyvitamin D was observed. She suffered from bone pain of two years duration beginning at 12 years of age and was found to be suffering from hypocalcemia, secondary hyperparathyroidism and osteomalacia. Laboratory findings revealed normal serum 25-hydroxyvitamin D (27 ng/ml) and markedly elevated serum 1,25-dihydroxyvitamin D (131.9 pg/ml). The hypocalcemia was refractory in spite of administration of 25,000 units of vitamin D2, but therapy with high doses of oral 1α-hydroxyvitamin D3 resulted in significant elevation of the serum calcium level. The clinical findings and course of the patient's disease were quite different from those of other patients with vitamin D dependent rickets reported by other authors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443263
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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