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  • 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline  (1)
  • Keywords: 1(N)-Amino-4-phenyl-1  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Oxidation of 1-amino-4-phenyl-1,2,3,6-tetrahydropyridine, a 1-amino analog of MPTP, by type A and B monoamine oxidase (1998)
    Springer
    Journal of neural transmission 105 (1998), S. 1253-1264 
    Details
    ISSN: 1435-1463
    Keywords: Keywords: 1(N)-Amino-4-phenyl-1 ; 2 ; 3 ; 6-tetrahydropyridine ; oxidation ; monoamine oxidase ; MPTP ; MPP+ ; human brain synaptosomes.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary. A 1-amino analog of MPTP, 1(N)-amino-4-phenyl-1,2,3,6-tetrahydropyridine, was synthesized and the oxidation was examined using human synaptosomal mitochondria as sources of type A and B monoamine oxidase. An oxidation product, 1-amino-4-phenylpyridinium ion, was quantified by high-performance liquid chromatography-fluorometric detection. The amino analog was a substrate of both type A and B monoamine oxidase and the oxidation depended linearly on the enzyme amount and the reaction time with an optimal pH around 7.5. After the systemic injection of the amino analog in C57/black mice for one week, 1-amino-4-phenylpyridinium ion was detected in the brain. 1(N)-Amino-4-phenyl-1,2,3,6-tetrahydropyridine was proved to be cytotoxic to pheochromocytoma PC12 cells, and it may be a new neurotoxin bioactivated through the oxidation by type A and B monoamine oxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007020050128
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  • 2
    Electronic Resource
    Electronic Resource
    Uptake of a neurotoxin-candidate, (R)-1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline into human dopaminergic neuroblastoma SH-SY5Y cells by dopamine transport system (1994)
    Springer
    Journal of neural transmission 98 (1994), S. 107-118 
    Details
    ISSN: 1435-1463
    Keywords: Uptake ; inhibition ; dopamine transporter ; 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline ; 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline ; 1,2-dimethyl-6,7-dihydroxyisoquinolinium ion ; neuroblastoma SH-SY5Y cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Uptake of catechol isoquinolines to dopamine cells was studied using human dopaminergic neuroblastoma SH-SY5Y cells. Only (R)-1,2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline [(R)-1,2-DiMeDHTIQ] was transported by dopamine uptake system, while (S)-1,2-DiMeDHTIQ, (R)- and (S)-1-methyl-6,7-dihydroxy-tetrahydroisoquinoline, and 1,2-dimethyl-6,7-dihydroxyisoquinolinum ion were not. Kinetical study showed that the uptake of (R)-1,2-DiMeDHTIQ followed the Michaelis-Menten equation, and the values of the Michaelis constant and the maximal velocity were obtained to be 102.6 ± 36.9 μM and 66.0 ± 2.8 pmol/min/mg protein. Dopamine was found to inhibit (R-1-DiMeDHTIQ uptake competitively. These results suggest that the selective uptake by dopamine transporter may account for the specific neurotoxicity of (R)-1,2-DiMeDHTIQ to dopamine neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277014
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    Paper (German National Licenses)
    Fulltext
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