ISSN:
1573-7373
Keywords:
melanoma PET
;
18F-DOPA analogue
;
melanoma neutron capture therapy
;
10B-p-boronophenyl-alanine
;
malignant melanoma
;
melanoma brain metastasis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Detection and diagnosis of human malignant melanoma byPositron Emission Tomography (PET) using 18F-10B-L-BPA, a specificmelanogenesis-seeking compound synthesized for use in Boron NeutronCapture Therapy for malignant melanoma (NCT), has beendeveloped. This resulted in a novel, highly effectivemethodology for the selective three dimensional imaging ofmetastatic malignant melanomas, and for accurate determination of10B concentration in the tumor and surrounding tissue,providing almost all diagnostic information necessary for completenon-invasive radiation dose planning in the treatment ofmalignant melanoma both for NCT as well asother therapeutic modalities.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1005746020350
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