ISSN:
1432-069X
Keywords:
Dithranol
;
Psoriasis
;
Arachidonic acid
;
12-Hydroxyeicosatetraenoic acid
;
Leukotriene B4
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The concentrations of arachidonic acid and its lipoxygenase metabolites were measured in exudates from lesional psoriatic skin during treatment with 0.25% dithranol (anthralin) applied topically for 10 days. Dithranol caused a reduction in the concentration of arachidonic acid at 10 days (167±42 and 358±55 ng ml-1 treated and control sites respectively, p〈0.05) concurrent with clinical improvement of the lesions. Neither 12-hydroxyeicosatetraenoic acid nor leukotriene B4 concentrations were significantly affected. These results do not support the view that lipoxygenase products are of major importance in the pathogenesis of psoriasis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00427659
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