ISSN:
1432-0584
Keywords:
Acute lymphoblastic leukemia
;
Antibodies
;
125I protein A binding assay
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a 125I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bound significantly to ALL leukemic cells (6/7 positive combinations), but not to AML leukemic cells (8/8 negative combinations). We propose that ALL sera contain antibodies binding to autologous leukemic cells and that they are directed against a common ALL antigen(s).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00320780
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