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  • 1
    Electronic Resource
    Electronic Resource
    Microorganisms as reagents for transformations of 5α-steroids (1994)
    Springer
    Russian chemical bulletin 43 (1994), S. 515-537 
    Details
    ISSN: 1573-9171
    Keywords: 5α-pregnanes ; 9α-hydroxysteroids ; dehydrogenation ; Arthrobacter ; Nocardia ; Rhodococcus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Microbial activation of rings A, B, and C of 5α-steroids is reviewed in connection with the prospects for the use of 5α-steroids as a new starting material for the manufacturing of steroidal medicinal preparations. The combination of chemical synthesis and microbial methods of steroid transformation allows the successful solution of the problem of selective functionalization of steroid molecules, provided the suitable microorganisms are chosen and the conditions of their cultivation are optimized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00699817
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Transformed steroids. 193. Synthesis of 16α,17α-isopropylidene derivatives of pregn-4-ene-9α,16α,17α,21-tetraol-3,20-dione and its 17α-thioanalog (1992)
    Springer
    Russian chemical bulletin 41 (1992), S. 1916-1919 
    Details
    ISSN: 1573-9171
    Keywords: 9α-hydroxy-16α,17α-epoxypregnanes ; 16α,17α-isopropylidene derivatives of 9α-hydroxypregnanes and their thioanalogs ; cis-cleavage of acetic and thioacetic acid ; 20-carboethoxyhydrazone of 16α,17α-epoxypregnane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A study was carried out on the pathways for the transformation of 16α,17α-epoxypregn-4-ene-9α,21-diol-3,20-dione to give 16α,17α-isopropylidene derivatives of pregn-4-ene-9α,16α,17α,21-tetraol-3,20-dione and its 17α-thioanalog. The key step in this pathway is thecis-cleavage of the 20-carboethoxyhydrazone of this epoxide by acetic and thioacetic acids and subsequent condensation of the products formed with acetone. This pathway is an efficient approach to the synthesis of the 16α,17α-dioxolane derivative and is equally efficient for preparation of the thioanalog, namely, 16α,17α-isopropylidenepregn-4-ene-9α,16α,21-triol-17α-thiol-3,20-dione, which has already been synthesized by an alternative method.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00863832
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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