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  • Cell & Developmental Biology  (3)
  • 17β-hydroxy-2-hydroxy methylene-17α-methyl-5α-androstan-3-one  (1)
  • 2α-cyano-17β-hydroxy-4,4,17α-trimethylandrost-5-en-3-one  (1)
  • Animal model  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The effects of specific inhibitors and an antiserum of 3β and 17β-hydroxysteroid dehydrogenase on steroid uptake in Pseudomonas testosteroni
    Amsterdam : Elsevier
    Journal of Steroid Biochemistry 10 (1979), S. 519-522 
    Details
    ISSN: 0022-4731
    Keywords: 1,3,5 (10)-estratriene-3,17α-diol ; 17β-hydroxy-2-hydroxy methylene-17α-methyl-5α-androstan-3-one ; 17β-hydroxy-4-androsten-3-one ; 17β-hydroxy-5β-androstane-3-one ; 2α-cyano-17β-hydroxy-4,4,17α-trimethylandrost-5-en-3-one ; 3,4-Bis (4-hydroxyphenyl)-3-hexene ; 3β-hydroxy-5-androsten-17-one ; Cyanoketosteroid ; Dehydroepiandrosterone ; Diethylstilbestrol ; Dihydrotestosterone ; Estradiol-17α ; Hydroxymethylenesteroid ; Testosterone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-4731(79)90213-9
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  • 2
    Electronic Resource
    Electronic Resource
    Coonhound paralysis (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 167-178 
    Details
    ISSN: 1432-0533
    Keywords: Comparative neurology ; Acute idiopathic polyradiculoneuritis ; Animal model ; Guillain-Barré syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prior study of coonhound paralysis (CHP) revealed an acute polyradiculoneuritis in raccoonhunting dogs with clinical and pathologic features resembling those of Guillain-Barré syndrome (GBS). In the present series of five cases, the clinical features were investigated with emphasis on electrodiagnostic and CSF findings, and pathologic changes were evaluated with both the light and electron microscope. The demonstration of motor nerve conduction delay and CSF albuminocytologic dissociation in affected dogs further supported the clinical similarity of CHP and GBS. As in GBS, affected roots and nerves contained mononuclear cell infiltrates, segmental myelin changes and axon degeneration. Despite these general pathologic similarities, the present study suggested that axon damage was a more consistent finding in CHP than in GBS. In contrast to ultrastructural findings in GBS, the demyelinating process in CHP did not appear dependent upon macrophages for its initiation. Swelling, separation and vesiculation of myelin occurred around axons of reduced diameter often in the absence of proximate macrophages. Macrophages, rather than initiating demyelination, appeared to be superimposed on existing damage. In this regard, the observed changes resembled those reported in galactocerebroside-induced EAN and seramediated in vivo demyelination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690632
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Ultrastructural characterization of glial cells in the rat pineal gland with special reference to the pineal stalk (1984)
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 210 (1984), S. 663-674 
    Details
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: In the present study the “interstitial” cells of the superficial pineal gland and the nonparenchymal cells of the pineal stalk in Sprague-Dawley rats were examined ultrastructurally with the aim of defining the cells more closely. The “interstitial” cells of the superficial pineal gland do not represent a homogeneous cell population. The most abundant cell type is the mononuclear phagocyte, most easily recognized by its dark appearance and its content of primary and conspicuous secondary lysosomes. Astrocytes can be distinguished by the typical appearance of their nuclei (i.e., a thin continuous rim of heterochromatin adjacent to the nuclear membrane), identical to that of astrocytes in the CNS. Depending on the absence or presence of glial filaments and their amount, a spectrum of astrocytic cells is present. Mature astrocytes with filaments throughout their cytoplasm are rare. Immature glial cells with few or no filaments predominate. In the vicinity of blood vessels pericytes are present. In view of the fact that the “interstitial” cells could generally be identified it is suggested to abandon the term interstitial for the cells in question. In the pineal stalk mature astrocytes predominate; they have some features in common with pinealocytes, i.e., the presence of intergrade endoplasmic reticulum and grumose bodies (lysosomes). Other unusual features are a relative abundance of coated pits and vesicles. Oligodendrocytes are restricted to the proximal part of the stalk, near the deep pineal, where myelinated axons are abundant. More distally a few Schwann cells were seen.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ar.1092100414
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  • 4
    Electronic Resource
    Electronic Resource
    “Synaptic” ribbons and spherules of the guinea pig pineal gland: Inverse day/night differences in number (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 168 (1983), S. 67-74 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The present study deals with the functionally enigmatic “synaptic” ribbons and spherules of guinea pig pinealocytes. Whereas the ribbons have been shown to exhibit a 24-hr rhythmicity with low numbers during the day and high numbers at night, very little of a definitive nature is known about the spherules. Sixteen male guinea pigs of the Hartley strain were perfusion fixed, 8 between 0900-1100 hr, and 8 between 2100-2300 hr. The ribbons and spherules were counted in the pineal parenchyma of the proximal, intermediate, and distal regions. In confirmation of earlier studies, it was found that “synaptic” ribbons are equally abundant in the proximal, intermediate, and distal regions of the gland, during both the day and the night, and that they increase significantly in number at night when compared with daytime values. The spherules, by contrast, are more abundant proximally and are present in greater numbers during the day than at night. As ribbons and spherules are usually not found in one and the same pinealocytic profile, and based on previous electrophysiological studies, it is proposed that the ribbons are morphological markers of nocturnally active pinealocytes, whereas spherules characterize diurnally active pinealocytes.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001680107
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  • 5
    Electronic Resource
    Electronic Resource
    Prenatal development of “synaptic” ribbons in the guinea pig pineal gland (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    American Journal of Anatomy 187 (1990), S. 39-54 
    Details
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Pineal “synaptic” ribbons are a heterogeneous population of organelles. “Synaptic” ribbons (SR) sensu stricto, “synaptic” spherules (SS), and intermediate forms (IMF) are present. Their function and origin are unknown, and a knowledge of their prenatal development is lacking. Thus the pineal glands of prenatal, neonatal, and adult guinea pigs were prepared for electron microscopy. “Synaptic” ribbons were studied morphologically and quantitatively. The three categories of “synaptic” ribbons reported in adult pineal glands were also present in prenatal pineal glands. Their structural features, distribution, grouping, and composition patterns are similar to those in adults. “Synaptic” ribbons were first detected in pinealocytes of the distal region of a 42-day postcoitus (PC) pineal gland and were comparable with those in adults. They increased in number with age and reached a peak at 63 days PC, followed by a steep decline at 66 and 67 days PC. By day 69 PC, the numbers increased again and showed a dramatic increase after birth. Several true ribbon synapses were seen at day 63 PC between pinealocyte cell processes or between pinealocyte cell process and pinealocyte cell body. Since true ribbon synapses have not been found in adult guinea pig pinealocytes, their synaptic nature could have been lost during development. No precursors for the “synaptic” ribbons were found. The endoplasmic reticulum cisternae may be the origin for the ribbon vesicles because of their close association with the “synaptic” ribbons.
    Additional Material: 22 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aja.1001870106
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