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  • 1
    Electronic Resource
    Electronic Resource
    A Solution and Solid State Study on 2-Hydroxypropyl-β-Cyclodextrin Complexation with Hyodeoxycholic Acid (2000)
    Springer
    Journal of inclusion phenomena and macrocyclic chemistry 37 (2000), S. 237-251 
    Details
    ISSN: 1573-1111
    Keywords: hyodeoxycholic acid ; 2-Hydroxypropyl-β-cyclodextrin ; Inclusion complex ; Solubility studies ; 13C- and 1H-NMR spectroscopy ; Circular dichroism ; IR spectroscopy ; X-ray diffractometry ; Thermal analysis ; Dissolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Hyodeoxycholic acid (HDCA) isa 6-α dihydroxylated natural bile acid capable ofpreventing gallstone formation by reducing the bilecholesterol saturation. However, any attempt to enrichthe bile acid pool with HDCA have failed owing to thepoor solubility of the molecule. To resolve thebioavailability problems, the complexation of HDCAinto the HPβCD cavity was studied in solution(solubility methods, 13C- and 1H-NMRspectroscopy and circular dichroism) and in the solidstate (IR spectroscopy, X-ray diffractometry andthermal analysis). According to the results, the HDCAinclusion took place with 1 : 1 stoichiometry. Theinfluence of different preparation methods of thesolid complex was evaluated for its potential use inappropriate pharmaceutical formulations to improve thebioavailability of HDCA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008162912495
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  • 2
    Electronic Resource
    Electronic Resource
    Complete assignment of the aliphatic chains in dimers, trimers and polymer of 3-hexylthiophene through 2D-NMR spectroscopy (1995)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 33 (1995), S. 657-663 
    Details
    ISSN: 0749-1581
    Keywords: NMR ; 1H NMR ; 13C NMR ; dimers and timers of 3-hexylthiophene ; poly(3-hexylthiophene) ; 1H, 13C inverse detection ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 1H and 13C signals of the hexyl chains of the title compounds were fully assigned. The regiochemical features of the aliphatic region of proton and carbon spectra were analysed in dimers and trimers. Dimers and trimers proved to be reliable model compounds in the regiochemical assignment of poly(3-hexylthiophene) even when the aliphatic region of proton and carbon spectra was involved. The chemical shifts of the protons of CH2(α)s and of the hexyl chain as a whole and those of the first three aliphatic carbons appear to be the most significant.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260330807
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    Paper (German National Licenses)
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