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  • 1
    ISSN: 1432-1920
    Keywords: Key words Spine ; infections ; Spine ; neoplasms ; Tuberculosis ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed MRI studies of 60 patients presenting with extradural compressive myeloradiculopathy secondary to vertebral disease to assess the imaging features which may help in differentiating tuberculous from neoplastic disease. Spin-echo T1-, proton density- and T2-weighted images were available for all patients and fast low-angle shot images with a low flip angle for 21 patients. Contrast-enhanced images were available for 28 patients. There were 41 patients with tuberculosis and 19 patients with neoplastic disease (metastases 11, lymphoma 6, plasmacytoma 1, and giant cell tumour 1). Discovertebral disease with or without involvement of the posterior arch was a feature not only of tuberculous spondylitis (30 patients) but also of metastases (6). The remaining 11 patients with tuberculosis had “atypical” involvement (vertebral body with or without posterior arch in 8 and posterior arch alone in 3) described as typical of neoplasms. This “typical” involvement was seen in metastases (5), lymphoma (6) and the 2 primary bone tumours. The presence of an abscess helped in differentiating tuberculosis from neoplasia in 22 of the 41 patients with tuberculosis and was absent in all with neoplasms. The presence of bone fragments in 16 patients (8 with and 8 without an abscess) was found to be specific for tuberculosis. In the absence of an abscess or bone fragments, image-guided biopsy is essential to establish the diagnosis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1920
    Keywords: Spine, infections ; Spine, neoplasms ; Tuberculosis ; Computed tomography ; Magnetic resonance imaging
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We reviewed MRI studies of 60 patients presenting with extradural compressive myeloradiculopathy secondary to vertebral disease to assess the imaging features which may help in differentiating tuberculous from neoplastic disease. Spinecho T1-, proton density- and T2-weighted images were available for all patients and fast low-angle shot images with a low flip angle for 21 patients. Contrast-enhanced images were available for 28 patients. There were 41 patients with tuberculosis and 19 patients with neoplastic disease (metastases 11, lymphoma 6, plasmacytoma 1, and giant cell tumour 1). Discovertebral disease with or without involvement of the posterior arch was a feature not only of tuberculous spondylitis (30 patients) but also of metastases (6). The remaining 11 patients with tuberculosis had “atypical” involvement (vertebral body with or without posterior arch in 8 and posterior arch alone in 3) described as typical of neoplasms. This “atypical” involvement was seen in metastases (5), lymphoma (6) and the 2 primary bone tumours. The presence of an abscess helped in differentiating tuberculosis from neoplasia in 22 of the 41 patients with tuberculosis and was absent in all with neoplasms. The presence of bone fragments in 16 patients (8 with and 8 without an abscess) was found to be specific for tuberculosis. In the absence of an abscess or bone fragments, image-guided biopsy is essential to establish the diagnosis.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0749-1581
    Keywords: steroids ; 1H NMR ; 13C NMR ; coupling constants ; conformational analysis ; 1D TOCSY ; NOE ; cyclosteroids ; cyclopropanosteroids ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Proton and carbon NMR data are provided for 21 ring A and ring B cyclosteroids and cyclopropano (or methylene) steroids. Shift assignments were made using standard 2D NMR techniques, while ring A proton subspectra were extracted with a 1D TOCSY experiment. Coupling constants were obtained from iterative spin system simulation of these sub-spectra. Ring A conformations were determined from the two- and three-bond proton-proton couplings and NOE measurements. The utility and limitations of extended Karplus-type equations, the effect of cyclopropyl groups on vicinal and geminal couplings and cyclopropane-induced chemical shifts are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0749-1581
    Keywords: 1H NMR ; 13C NMR monomethyl/dimethyl 5α-androstan-3-ones ; Steroid ; Ring A conformation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Ring A proton shifts and couplings and 13C shifts of all carbons are given for 17β-acetoxy-2α-methyl- and 17β-methoxy-2β-methyl-5α-androstan-3-one and 2,2-dimethyl-17β-methoxy-5α-androstan-3-one. It was concluded that the 2β-methyl derivative exists with ring A in a regular chair conformation while the 2β-methyl derivative exists with ring A in an inverted boat conformation with C-2 and C-5 at the bow/stern positions. The data for 2,2-dimethyl-17β-methoxy-5α-androstan-3-one suggest an equilibrium of these two conformers.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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