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  • Hematopiesis  (2)
  • 1H and 2H solid-state nuclear magnetic resonance  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis (1995)
    Springer
    Annals of hematology 70 (1995), S. 309-312 
    Details
    ISSN: 1432-0584
    Keywords: Interleukin-6 ; Aplasia ; Bone marrow transplantation ; Hematopiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (≥38° C) of presumed infectious origin with an average of 74±60 units/ml (range 19–309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118±254 units/ml, range 17–1213 units/ml) were not significantly higher than those found in the febrile BMT group (p〉0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (≥1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (〈1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696617
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis (1995)
    Springer
    Annals of hematology 70 (1995), S. 309-312 
    Details
    ISSN: 1432-0584
    Keywords: Key words Interleukin-6 ; Aplasia ; Bone marrow transplantation ; Hematopiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (≥38°  C) of presumed infectious origin with an average of 74±60 units/ml (range 19–309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118±254 units/ml, range 17–1213 units/ml) were not significantly higher than those found in the febrile BMT group (p〉0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (≥1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (〈1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01696617
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Different types of water in the film formation process of latex dispersions as detected by solid-state nuclear magnetic resonance spectroscopy (2000)
    Springer
    Colloid & polymer science 278 (2000), S. 236-244 
    Details
    ISSN: 1435-1536
    Keywords: Key words Latex dispersions ; Film formation ; 1H and 2H solid-state nuclear magnetic resonance ; Water in polymer films
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  The properties of polymer films prepared from latex dispersions are influenced by the drying or film formation process. In order to investigate this process, various systems of aqueous latex dispersions were dried until a specific solid content was reached. The samples investigated were based on vinyl acetate, vinyl acetate/ethylene and pure acrylics employing different surfactants and polyelectrolytes as stabilisers of the dispersions. The role of water in these partially dried films was investigated using 1H and 2H solid-state NMR spectroscopy. Different types of water could be distinguished in the spectra. The drying latex films were found to contain interfacial external water, water at ionic and nonionic groups at surfactants in the polymer/water interface and also water inside the swollen polymer. These different types of water were examined separately using various NMR techniques.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003960050037
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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