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  • Extracellular matrix  (4)
  • 2,3-dibenzylbutane.  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Neolignans from Virola calophilloidea
    Amsterdam : Elsevier
    Phytochemistry 24 (1985), S. 1867-1868 
    Details
    ISSN: 0031-9422
    Schlagwort(e): 2,3-dibenzylbutane. ; 4-aryltetralins ; Myristicaceae ; Virola calophylloidea ; neolignans
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)82578-9
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  • 2
    Digitale Medien
    Digitale Medien
    Immunofluorescent localization of tenascin during the morphogenesis of the outflow tract of the chick embryo heart (1990)
    Springer
    Anatomy and embryology 181 (1990), S. 149-155 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Heart morphogenesis ; Truncus Arteriosus ; Extracellular matrix ; Tenascin ; Collagen type I
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The cono-truncus constitutes a complex segment of the developing heart that gives rise to the outflow tract of the ventricles and root of the pulmonary and aortic arteries. Numerous studies have revealed that the extracellular matrix plays a relevant role in most morphogenetic processes modulating cell behaviour. By means of immunofluorescence, we studied the distribution and possible involvement of tenascin during morphogenesis of the conus and truncus in chick embryo hearts between days 4.5–10 of incubation. Tenascin is an extracellular matrix glycoprotein with a significant role in morphogenesis and cell and tissue differentiation. Our results reveal a specific distribution of tenascin in the areas of the cono-truncus undergoing significant structural changes during morphogenesis of this cardiac segment, appearing mainly in the mesenchymal layer subjacent to the myocardial layer, the cono-truncal ridges and the aorto-pulmonary septum. The distribution of tenascin was compared and contrasted with that of collagen type I, which constitutes a further component of the extracellular matrix common to most developing connective tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00198954
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  • 3
    Digitale Medien
    Digitale Medien
    Structural arrangement of the extracellular matrix network during myocardial development in the chick embryo heart (1991)
    Springer
    Anatomy and embryology 184 (1991), S. 451-460 
    Details
    ISSN: 1432-0568
    Schlagwort(e): Extracellular matrix ; Ventricular myocardium ; Chick embryo
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We analyzed the extracellular matrix and the connective tissue of the developing chick myocardium (“myocardial interstitium”). The importance of this myocardial element for heart function has been well documented both for the normal and pathologic adult hearts. However, little information is available on the organization of the embryonic myocardial interstitium and its modifications during development and increasing intracardiac pressure. In the present study we used light and scanning electron microscopic techniques, and lectin probes to study the interstitium of the ventricular myocardium of chick embryos from stage 29 (day 6 of development) until hatching. Our observations trace the progressive appearance and organization of the elements of the extracellular matrix, comprising the epimysium, perimysium and endomysium, which form a well-defined architectural network. Finally, we discuss the role of these elements of the extracellular matrix and their possible relation with the biomechanical properties of developing heart.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01236051
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  • 4
    Digitale Medien
    Digitale Medien
    Histogenesis of the semilunar valves: an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves (1990)
    Springer
    Cell & tissue research 259 (1990), S. 299-304 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Semilunar valves ; Extracellular matrix ; Tenascin ; Type-I collagen ; Heart morphogenesis ; Domestic fowl
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The development of the semilunar valves takes place in association with septation of the outflow tract in the embryonic heart. Although numerous studies have focused on this process, the causal mechanisms of valvular development remain obscure. This paper reports an immunohistochemical analysis of tenascin and type-I collagen distribution in developing chick heart valves. Tenascin is a glycoprotein that is present on some embryonic extracellular matrices. It plays several significant roles in tissue differentiation, cell growth, and tissue interactions; it is also important for the formation of specific zones of connective tissue that fulfill mechanical functions. Our results show that tenascin is present during valvular morphogenesis and histogenesis, and that its distribution is associated with zones specialized in bearing mechanical loads.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00318452
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  • 5
    Digitale Medien
    Digitale Medien
    Extracellular matrix arrangement in the papillary muscles of the adult rat heart. Alterations after doxorubicin administration and experimental hypertension (1994)
    Springer
    Basic research in cardiology 89 (1994), S. 279-292 
    Details
    ISSN: 1435-1803
    Schlagwort(e): Extracellular matrix ; papillary muscle ; rat heart ; doxorubicin ; hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In the present study, we analyzed the components of the extracellular matrix (ECM) and its arrangement at the level of the papillary muscles in the adult rat heart using light and transmission and scanning electron microscopy techniques. Our results reveal that after a single dose (6 mg/kg) of dexorubicin to cause a significant decrease and disorganization of the endomysium and perimysium in the first week after injection, affecting the endomysial struts and perimysial strands. Degenerating myocytes and alterations of the coiled perimysial fibers were characteristic 4 weeks after treatment. After 8 weeks, ultrastructural alterations at the level of the plasma membrane of the myocytes and adjacent collagen network were present in the tip of the papillary muscles. These alterations may be responsible for the inefficiency of the valvular apparatus as an initial factor implicated in doxorubicin-induced congestive heart failure. Experimental hypertension, produced by constriction of the abdominal aorta, induced hypertrophy of the left ventricle, with increased perimysium and endomysium of the ECM at the level of the papillary muscles 4 weeks after aortic banding. Interstitial and perivascular fibrosis were observed 8 weeks after surgical treatment, and macrophages around the degenerating myocytes were characteristic 16 weeks after treatment. These alterations of the ECM network have been correlated with their possible implication in ventricular biomechanical properties.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00795198
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