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Digitale Medien

An experimental study of the pathogenesis of the selective lesion of the globus pallidus in acute carbon monoxide poisoning in cats (1983)

Song, S. -Y. ; Okeda, R. ; Funata, N. ; [weitere]

Springer

Acta neuropathologica 61 (1983), S. 232-238

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ISSN: 1432-0533

Schlagwort(e): Selective lesion of the globus pallidus ; Acute carbon monoxide poisoning ; Cerebral local blood flow ; Hydrogen clearance method

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Twenty-eight mature cats were exposed to 0.3% carbon monoxide (CO) gas for 90–193 min using artificial ventilation. The systemic blood pressure (BP), venous pressure (VP), blood flow of the left common carotid artery (CF), and blood gas were monitored. The local blood flow (LBF) of the globus pallidus, putamen, or claustrum was measured by the hydrogen clearance method. Pallidal lesions were found histologically in 14 cats. The period of CO inhalation and the time thereafter were divided into the following four stages in the animals with pallidal lesions. Stage 1: Initial phase with rapid increase in the CF and LBF, and rapid decrease in the BP. Stage 2: Middle phase with slow decrease in the BP, CF, and LBF. Stage 3: Terminal phase with rapid decrease in the BP, CF, and LBF. Stage 4: Recovery phase. The changes in stage 3 were not so prominent in the animals without pallidal lesions. The LBF of the globus pallidus of the animals with lesions decreased to 67.3±20.7% of the initial value at the terminal stage of CO inhalation, while it was 188±46.7% in those without lesions. The difference was statistically significant (P〈0.01). The LBF of the putamen or claustrum in the animals with lesions in the globus pallidus was 140±24.6% at this stage, and it was significantly higher than that of the globus pallidus (P〈0.01). Other factors, such as CO inhalation time, degree of acidosis, and terminal CO-Hb concentration, did not correlate with the occurrence of the pallidal lesion.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00691991

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Digitale Medien

Effect of intramolecular and intermolecular exchange processes on the 1H NMR spectra of 2-chloro-1,3,2-dioxarsolanes (1987)

Song, S. K. ; Watkins, C. L. ; Krannich, L. K.

Chichester : Wiley-Blackwell

Organic Magnetic Resonance 25 (1987), S. 484-488

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ISSN: 0749-1581

Schlagwort(e): 1H NMR ; 13C NMR ; 2-Chloro-1,3,2-dioxarsolanes ; Intra- and inter-molecular exchange ; Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The 1H and 13C NMR spectra of solutions of 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxarsolane (1) and 2-chloro-1,3,2-dioxarsolane (2) are reported as a function of temperature, concentration and solvent. These data indicate rapid intramolecular conformational averaging for (1) and (2) under all the conditions investigated. Additionally, intermolecular conformational averaging processes are shown to be present. The kinetic parameters for intermolecular exchange were obtained from line shape analysis of the 1H NMR data. These results indicate the intermolecular exchange to be bimolecular in nature, involving a four-centered transition state. The O—CH2—CH2-O torsional angle of (2) has been calculated from the analysis of its AA′BB′ 1H NMR spectral patterns, obtained at low concentrations in the absence of intermolecular exchange.

Zusätzliches Material: 2 Ill.