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  • 1
    Electronic Resource
    Electronic Resource
    HLA antigens and intracranial aneurysms (1992)
    Springer
    Acta neurochirurgica 116 (1992), S. 1-5 
    Details
    ISSN: 0942-0940
    Keywords: Intracranial aneurysm ; HLA complex ; auto-immunoaggression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The frequencies of the HLA-A, -B and -DR were determined in a group of 59 transplant donors who died from subarachnoid haemorrhage within three days following the rupture of intracranial aneurysm (the SAH group) and compared with those of a control group consisting of 389 donors who died from other causes. The only significant difference was in the increased frequency in the SAH group of non-typed (“empty”) -DR loci in association with the DR7 phenotype. The most probable explanation of this finding is that in the SAH group the frequency of DR7 homozygotes is several times higher than in the general population, and that bearing the DR7 allele in homozygotic form is associated with a very high risk of developing potentially fatal intracranial aneurysmal haemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01541246
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    2-Chloro-2′ deoxyadenosine prevents angiopathic changes in cerebral arteries in experimental SAH in rabbits (1993)
    Springer
    Acta neurochirurgica 122 (1993), S. 118-121 
    Details
    ISSN: 0942-0940
    Keywords: SAH ; cerebral angiopathy ; immunosuppression ; 2-chloro-2′-deoxyadenosine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We compared the morphology of the basilar artery walls in rabbits with experimental subarachnoid haemorrhage (SAH) without and with concomitant treatment with a novel immunosuppressive drug, 2-chloro-2′-deoxyadenosine (2 CdA). The treatment was successful in the prevention of the angiopathic changes, most likely due to its ability to inhibit lymphocyte activation in response to mitogenic signals. Since lymphocyte (and monocyte?) activation may play an important role in the development of the delayed neurological deficits in patients following SAH, the use of 2 CdA to prevent these deficits shall be considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01446997
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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