ISSN:
1432-0983
Keywords:
2-deoxyglucose
;
2-deoxyglucose-6P phosphatase
;
Catabolite repression
;
Saccharomyces cerevisiae
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract 2-deoxyglucose (2-DOG), a non-metabolize analogue of glucose, is taken up by yeast using the same transporter(s) as glucose and is phosphorylated by hexokinases producing 2-deoxyglucose-6-P. We found that in DOG R yeasts, 2-DOG was not able to trigger glucose repression, even at concentrations of 0.5%. This result suggests that the specific 2-DOG-6P phosphatase, the enzyme responsible for the DOG R phenotype, may be involved in inhibiting the process of catabolite repression mediated by 2-DOG
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315774
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