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  • 21.10.Ma  (4)
  • polymerase chain reaction  (3)
  • Achlys triphylla  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Four flavonol glycosides fromAchlys triphylla
    Amsterdam : Elsevier
    Phytochemistry 31 (1992), S. 301-303 
    Details
    ISSN: 0031-9422
    Keywords: Achlys triphylla ; Berberidaceae ; Epimedinae ; chemotaxonomy ; flavonol glycosides
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0031-9422(91)83058-S
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  • 2
    Electronic Resource
    Electronic Resource
    Four flavonol glycosides from Achlys triphylla
    Amsterdam : Elsevier
    Phytochemistry 31 (1991), S. 301-303 
    Details
    ISSN: 0031-9422
    Keywords: Achlys triphylla ; Berberidaceae ; Epimedinae ; chemotaxonomy. ; flavonol glycosides
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(91)83058-S
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Abnormal messenger ribonucleic acid (mRNA) transcribed from a mutant insulin receptor gene in a patient with type A insulin resistance (1992)
    Springer
    Diabetologia 35 (1992), S. 639-644 
    Details
    ISSN: 1432-0428
    Keywords: Insulin receptor ; type A insulin resistance ; deletion ; polymerase chain reaction ; insulin receptor gene ; direct sequence ; mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a previous report on a 16-year-old Japanese girl with type A insulin resistance, we found that one allele of the insulin receptor gene was inherited from her mother and contained a 1.2 kilobase pair deletion which removed the 14th exon in the β subunit. We extended investigation of the proband and found the deletion between two Alu sequences. To determine the effect of the deletion on the level of transcription and the splicing pattern of messenger ribonucleic acid (mRNA), we synthesized the complimentary DNA and used the polymerase chain reaction to amplify the region which included the deleted area. The deletion shifted the reading frame, resulting in a termination codon after amino acid 867 (Glu), thereby producing a truncated insulin receptor without a transmembrane region and cytoplasmic domain. We also sequenced each of 22 exons of the insulin receptor gene but found no mutation in exons of the insulin receptor gene, except for deletion of exon 14 of the maternal allele. Thus, the proband is a heterozygote for a single mutant allele. Abnormal mRNA transcribed from the mutant allele resulted in a decrease in insulin binding.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400255
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  • 4
    Electronic Resource
    Electronic Resource
    Type 2 (non-insulin-dependent) diabetes mellitus associated with a mutation of the glucokinase gene in a Japanese family (1993)
    Springer
    Diabetologia 36 (1993), S. 433-437 
    Details
    ISSN: 1432-0428
    Keywords: Glucokinase gene ; mutation ; Type 2 (non-insulin-dependent) diabetes mellitus ; polymerase chain reaction ; single stranded conformation polymorphism ; insulin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mutations were screened for in the glucokinase gene of 25 Japanese patients with Type 2 (non-insulin-dependent) diabetes mellitus. Each exon was scanned by electrophoresis of enzymatically amplified DNA segments under non-denaturing conditions and variants were sequenced. A variant pattern was detected in exon 5 of one patient. Direct sequencing of this exon revealed a single nucleotide substitution in codon 188 (GCT→ACT) of one of two alleles resulting in the mutation of Ala188→Thr, an invariant residue in the sequence of all mammalian glucokinases and hexokinases. This mutation was not found in 40 normal control subjects. The proband had been diagnosed with Type 2 diabetes at the age of 62 years. Four other members of her family have the same mutation and all have Type 2 diabetes or impaired glucose tolerance. The youngest age at diagnosis of Type 2 diabetes in these other members was 13 years, suggesting that her pedigree was maturity-onset diabetes of the young (MODY). All subjects with the Thr188 mutation show a decreased insulin secretory response during oral glucose tolerance testing. Mutations in the glucokinase gene associated with Type 2 diabetes have been previously identified in Caucasian (French and British) subjects. This study indicates that mutations in this gene are also implicated in the development of Type 2 diabetes in Asians. Further studies are required to determine the frequency of mutations in glucokinase among Japanese patients with Type 2 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402280
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  • 5
    Electronic Resource
    Electronic Resource
    Average partial level density based on the random matrix model. Inclusion of realistic one-body spectrum and effect of particle escape (1989)
    Springer
    The European physical journal 333 (1989), S. 141-148 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 23.40.Hc ; 21.10.Ma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The effect of the realistic one-body spectrum is included in calculating the average partial level density, which has been so far obtained assuming degenerate one-body spectrum and GDE for the residual interaction. We show that such partial level densities are obtained by solving the extended saddle point equations which need inputs of the realistic one-body spectrum as well as the second moment of the ensemble. It is seen that the average partial level density is expressed in a convolution form of the partial level density for realistic one-body spectrum with the distribution which describes the effect by the random residual interaction. Calculations numerically performed show the improvement over the previous results. The effect of particle escape on the level density is also investigated and turns out to be practically negligible in precompound reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01565144
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  • 6
    Electronic Resource
    Electronic Resource
    Exciton level densities with spin and parity based on random matrix model (1991)
    Springer
    The European physical journal 339 (1991), S. 129-139 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 23.40.Hc ; 21.10.Ma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Level densities for fixedJ π and the exciton number are evaluated for closed shell nuclei40Ca and208Pb. The single particle spectra and wave functions are generated by Woods-Saxon potentials. The effects of the residual interaction are taken into account statistically by the method of generating function and Grassmann integral. The matrix elements for the residual interaction are assumed to be random variables with Gaussian distributions whose second moments are calculated by using a zero range interaction. The second moments are evaluated for fixedJ π by ignoring the Pauli principle between active nucleons and the spectator. This approximation is shown numerically to be very good. The partial level densities are calculated using the second moments as well as independent particle model spectra. The resulting level densities spread over wider energy ranges, have a smoother energy dependence and are enhanced at low energies compared with the independent particle model densities, although the total level densities do not differ by much.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01282942
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  • 7
    Electronic Resource
    Electronic Resource
    Studies of nuclear second moments for pre-equilibrium nuclear reaction theories — Extension to finite-range residual interaction (1988)
    Springer
    The European physical journal 330 (1988), S. 265-275 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 23.40.Hc ; 21.10.Ma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Study of the nuclear second moments, important inputs to pre-equilibrium reaction theories, is extended to residual interactions of finite range. The interactions are assumed to have general spin and isospin dependence. The second moments are found to be always positive definite for commonly used values of the interaction parameters. They seem to support the strong coupling limit of the pre-equilibrium reaction theory by Nishioka et al. [1], which would imply the modification of the phenomenological model used in analyzing experimental data. As an application of the second moments, it is also investigated how the nuclear level densities change with the parameter values of the residual interaction. The results show the important role of the residual interaction especially in the low energy region, which may greatly improve the agreement with experimental data at thermal neutron resonances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294869
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  • 8
    Electronic Resource
    Electronic Resource
    Studies of nuclear second moments for pre-equilibrium nuclear reaction theories (1987)
    Springer
    The European physical journal 327 (1987), S. 421-430 
    Details
    ISSN: 1434-601X
    Keywords: 24.60.Dr ; 23.40.Hc ; 21.10.Ma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The nuclear second moments, important inputs to pre-equilibrium reaction theories, are evaluated by assuming a simple model. The positive definite nature of the second moments is examined, and the nuclear level densities are calculated using positive definite second moments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01289568
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  • 9
    Electronic Resource
    Electronic Resource
    Expression of glycoprotein-processing enzymes in Escherichia coli as fusion proteins (1997)
    Springer
    World journal of microbiology and biotechnology 13 (1997), S. 265-267 
    Details
    ISSN: 1573-0972
    Keywords: β-1,4-galactosyltransferase ; fusion protein ; glycoprotein processing ; maltose binding protein ; man9-mannosidase ; polymerase chain reaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract A truncated Man9-mannosidase gene and a full-length β-1,4-galactosyltransferase gene were isolated from human kidney and placenta cDNAs, respectively. Both genes were cloned in plasmid pMAL-c2 to produce fusions with maltose-binding protein. Fusion products were purified by affinity chromatography. Purified enzymes were assayed using pyridyl-amino labelled oligosaccharides as substrates and analysed by HPLC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1018570604788
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