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  • 1
    Electronic Resource
    Electronic Resource
    The influence of catecholamines on Na, K transport in slow- and fast-twitch muscles of the rat (1983)
    Springer
    Pflügers Archiv 398 (1983), S. 236-240 
    Details
    ISSN: 1432-2013
    Keywords: Slow- and fast-twitch muscles ; Quabainsensitive and ouabain-insensitive86Rb influx ; 24Na and42K transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of catecholamines on active sodium and potassium transport was compared in slow- (SOL) and fasttwitch (EDL) skeletal muscles of the rat. Stimulation of active Na+-extrusion and K+-uptake induced by adrenaline (6–30 μmol · 1−1) and isoprenaline (1–40 μmol · l−1) was markedly greater in slow- than in fast-twitch muscle. In sodiumpreloaded muscles the maximal stimulation of24Na-efflux induced by adrenaline was about 2-fold higher in SOL than in EDL. Isoprenaline caused a 2.4-fold increase in ouabainsensitive86Rb influx in SOL muscle, but failed to alter the ouabain-sensitive influx in EDL. The stimulating action of isoprenaline on86Rb influx in EDL was due to an increase in the ouabain-insensitive fraction of Rb uptake. The effects of catecholamines of fast- and slow-twitch muscles were probably due to the accumulation of cyclic AMP, however the fact that there were no significant differences between the nucleotides levels in fast- and slow-twitch muscle suggests the participation of other mechanism as well. The results presented suggest that cyclic AMP-induced stimulation of ouabain-insensitive transport of cation in the isolated EDL muscle of the rat is similar to that of barnacle muscle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00657158
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  • 2
    Electronic Resource
    Electronic Resource
    Total Synthesis of the Toxin Oosponol and of Structural Analogues and Investigation of Their Antibiotic Activities (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 773-777 
    Details
    ISSN: 0947-3440
    Keywords: Gloeophyllum abietinum ; Oosponol ; Isocoumarin ; Structure-activity relationships ; Antibiotics ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The toxic metabolite of the basidiomycete Gloeophyllum abietinum, oosponol (6b), and the structural analogues (Figure 1) were synthesised in order to investigate which partial structures of the molecules are responsible for their biological activities. Different organisms were employed to test the antibiotic activities of the analogues. From the results obtained with the synthetic analogues of oosponol (6b), it became evident that the toxicity of this fungal metabolite can be attributed to a vinylogous acid anhydride structure, which in nature is produced by dehydrogenation of the nontoxic precursor oospoglycol (7).
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719970422
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  • 3
    Electronic Resource
    Electronic Resource
    Secondary Fungal Metabolites and Their Biological Activity, VIIIPart VII: J. Sonnenbichler, I. Zetl, D. Schwarz, Phytochemistry 1996, in press.. - Partial Synthesis of Oosponol, an Antifungal Isocoumarin (1997)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1997 (1997), S. 211-212 
    Details
    ISSN: 0947-3440
    Keywords: Isocoumarin ; Oosponol ; Pseudomonas fluorescens ; Antibiotics ; Secondary fungal metabolite ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The partial synthesis of oosponol (4), which shows significant antibiotic activity, has been accomplished by enzyme catalyzed reactions including regioselective acetylation of (-)-oospoglycol (1) followed by an oxidation step and hydrolysis by a lipase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199719970130
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    Paper (German National Licenses)
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