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  • 25-Dihydroxyvitamin D3  (1)
  • Giudicarie line  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Tectono-magmatic evolution of sheeted plutonic bodies along the north Giudicarie line (northern Italy) (1993)
    Springer
    International journal of earth sciences 82 (1993), S. 51-66 
    Details
    ISSN: 1437-3262
    Keywords: Tectono-magmatic evolution ; Plutonic bodies ; Giudicarie line
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Notes: Abstract Tectonized slices of foliated quartz-diorite/ quartz-gabbro rocks are exposed along the north Giudicarie line between Dimaro and Rumo (Western Trentino region, north-east Italy). They show geochemical and mineralogical similarities with the north-east corner of the Adamello batholith (Presanella pluton) and may be regarded as a northern apophysis lamella of Adamello. The intrusive bodies were emplaced within the Adria crust at a relatively shallow depth (approximately $$P_{{\text{H}}_{\text{2}} {\text{O}}} $$ equal to 3 kbar) along a proto-Giudicarie line under transtensive conditions during late Oligocene. Only near Rumo has contact metamorphism on the Austroalpine basement been observed, whereas in other outcrops it has been tectonically removed by later movements along the Giudicarie line. In the Samoclevolamella a magmatic flow texture, which developed during the emplacement of a crystal mush at shallow depth, is recorded by the preferred alignment of plagioclase and hornblende. A solid state foliation, outlined by quartz crystal aggregates, green hornblende and biotite, has been observed mostly in the Rumolamella. This indicates that a later ductile deformation, which developed under decreasing temperatures, overprinted the intrusive rocks. This deformation probably reflects late Oligocene strike-slip movements along the Tonale and Giudicarie lines. Finally semi-brittle to brittle deformation overprints the foliated igneouslamellae producing cataclasites and pseudotachylites. Sometimes these structures are subsequently cut by prehnite and epidote bearing veins. During this event, the intrusivelamellae were decoupled from their contact aureole and carried over the Insubric Flysch of the southern Alps. This last tectonic phase may be correlated to the Upper Miocene neo-Alpine transpressive event along the Giudicarie Line.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563270
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Upregulation of vitamin D receptor levels by 1,25(OH)2 vitamin D3 in cultured human keratinocytes (1997)
    Springer
    Archives of dermatological research 289 (1997), S. 367-372 
    Details
    ISSN: 1432-069X
    Keywords: Key words 1 ; 25-Dihydroxyvitamin D3 ; Vitamin D ; receptor ; Keratinocytes ; Vitamin D receptor mRNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The natural biologically active form of vitamin D3, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), possesses antiproliferative, prodifferentiating and immunomodulatory properties. The actions of 1,25(OH)2D3 are mediated through the intracellular vitamin D receptor (VDR), and the level of VDR is believed to determine the cellular responsiveness to vitamin D3. In the present study we examined the effects of 1,25(OH)2D3 on the expression of VDR and its message in cultured human keratinocytes. Western analysis showed the mean VDR content to be higher in undifferentiated cultures (175 pg/μg protein) than in differentiated cultures (90 pg/μg protein). Incubation with 1,25(OH)2D3 induced an increase in the VDR in both undifferentiated and differentiated keratinocytes. The VDR increase was detectable after 2 h and maximal (approximately two-fold stimulation) after 8 h. The 1,25(OH)2D3-induced stimulation of VDR levels was dose dependent with a maximum at 10–7 M. The VDR mRNA levels as determined by the ribonuclease protection assay showed a peak (50% stimulation) after approximately 2 h. Although this increase in VDR mRNA was not statistically significant, the results indicate that the ligand-induced upregulation of VDR involves increased transcription. The upregulation of VDR levels may increase the responsiveness to 1,25(OH)2D3 and may, therefore, be an important mechanism for regulating the effects of 1,25(OH)2D3 on keratinocyte proliferation and differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004030050206
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    Paper (German National Licenses)
    Fulltext
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