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  • 1
    Electronic Resource
    Electronic Resource
    Investigations on behavioral effects of an extract of Cannabis sativa L. in the rat (1981)
    Springer
    Psychopharmacology 75 (1981), S. 144-147 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; catecholamines ; Hyperreactivity ; Hyperthermia ; Pimozide ; Atropine ; 6-OHDA ; Stereotypy ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The behavioral responses of the rat to an extract of Cannabis sativa were examined after IP injection of 5, 15 and 30 mg/kg (expressed as Δ 9 tetrahydrocannabinol). The lowest dose of the extract induced stereotyped behavior (rhythmic head movements, intermittent gnawing and sniffing) together with hypersensitivity to stimuli and hyperthermia. The administration of higher doses of the extract resulted, initially, in similar behavioral effects but of greater intensity, followed by a cataleptic state alternating with atonic muscular prostration; rectal temperature was decreased. Pre-treatment with 6-hydroxydopamine (6-OHDA, which produces degeneration of catecholamine-containing nerve terminals) or pimozide (blocker of dopamine receptors) significantly reduced both stereotypy and hyperreactivity. Thermic effects were also antagonized by 6-OHDA pre-treatment. Cannabis-induced catalepsy was enhanced by pimozide but reduced by atropine (3 mg/kg SC). These results support the hypothesis that catecholamines play an important role in the complex behavioral effects of cannabis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432176
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Total cross sections of reactions induced by neutron-rich light nuclei (1989)
    Springer
    The European physical journal 332 (1989), S. 457-465 
    Details
    ISSN: 1434-601X
    Keywords: 21.10.-k ; 07.75.+h ; 21.10.Gv ; 25.70.Np ; 27.20.+n
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Total nuclear reaction cross-sections are determined by means of a 4π-γ method. The results cover a wide span of targets for various stable beams. The validity of the method is shown in a combined systematics including also the results of transmission-type experiments. The data are very well described by the formula developed by Kox et al. The same method is applied to secondary fragment beams produced from a 44 MeV/u22Ne beam on a 332mg/cm2 181Ta target. Using the LISE spectrometer the fragments4, 6He,6–9, 11Li,7, 9–12, 14Be,10–15, 17B11–19C,13–19N,15–21O,18– 21F and20,21 Ne are analyzed and transported to interact with a 199.4 mg/cm2 Cu target surrounded by a 4π-γ counter. The measured total reaction cross-sectionsσ R are discussed in terms of the reduced strong absorption radiusr 0 and compared with other experimental results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01292431
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    Paper (German National Licenses)
    Fulltext
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