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  • 27.50.+e  (1)
  • Bay K 8644  (1)
  • Bothrops neuwiedi  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Isolation: Analysis and Properties of Three Bradykinin–Potentiating Peptides (BPP-II, BPP-III, and BPP-V) From Bothrops Neuwiedi Venom (1998)
    Springer
    The protein journal 17 (1998), S. 285-289 
    Details
    ISSN: 1573-4943
    Keywords: Bradykinin ; BPPs ; Bothrops neuwiedi ; venom
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In the course of systematic investigations on low-molecular-weight compounds from the venom of Crotalidae and Viperidae, we have isolated and characterized at least three bradykinin-potentiating peptides (BPP-II, BPP-III, and BPP-V) from Bothrops neuwiedi venom by gel filtration on Sephadex G-25 M, Sephadex G-10 followed by HPLC. The peptides showed bradykinin-potentiating action on isolated guinea-pig ileum, for which the BPP-V was more active than of BPP-II, and BPP-III, rat arterial blood pressure, and a relevant angiotensin-converting enzyme (ACE) competitive inhibiting activity. The kinetic studies showed a K i of the order of 9.7 × 10−3 μM to BPP-II, 7 × 10−3 μM to BPP-III, and 3.3 ×10−3 μM to BPP-V. The amino acid sequence of the BPP-III has been determined to be pGlu-Gly-Gly-Trp-Pro-Arg-Pro-Gly-Pro-Glu-Ile-Pro-Pro, and the amino acid compositions of the BPP-II and BPP-V by amino acid analysis were 2Glu-2Gly-1Arg-4Pro-lIle and 2Glu-2Gly-lSer-3Pro-2Val-Ille, with molecular weight of 1372, 1046, and 1078, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022545020764
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The dihydropyridine derivative, Bay K 8644, enhances insulin secretion by isolated pancreatic islets (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 328 (1985), S. 351-353 
    Details
    ISSN: 1432-1912
    Keywords: Bay K 8644 ; Insulin secretion ; Mouse pancreatic islets
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the dihydropyridine derivative Bay K 8644 upon insulin secretion by perifused isolated mouse pancreatic islets were examined. At a non-stimulatory glucose concentration (5 mmol/l) Bay K 8644 (1 μmol/l) did not stimulate insulin release. However, the same drug concentration enhanced the insulin secretory responses to an intermediate (15 mmol/l) or high (30 mmol/l) glucose concentration by 80 or 90%, respectively. Bay K 8644 was half maximally effective at 0.1 μmol/l and maximally effective at 1 μmol/l. The results are compatible with the view that voltage-dependent calcium channels are essential for stimulus-secretion coupling in pancreatic B-cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00515566
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Precision measurement of the conversion electron spectrum of83m Kr with a solenoid retarding spectrometer (1992)
    Springer
    The European physical journal 342 (1992), S. 71-78 
    Details
    ISSN: 1434-601X
    Keywords: 27.50.+e ; 29.30.Dn
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This paper reports on precision measurements of conversion lines in the decay of83mKr with nuclear transition energies of 32.1 keV and 9.4 keV, respectively. The spectra were taken from a submonolayer surface of83m Kr frozen onto a cold backing, using the new Mainz solenoid retarding spectrometer. The high luminosity and resolution of this instrument enables the observation of all allowed conversion lines up to theN-shell and to fully separate the elastic component from inelastic satellites. The combined analysis of the data yields the transition energiesE y=32151.5±1.1 eV and 9405.9±0.8 eV, respectively. The experiment served also to pilot the application of this spectrometer to the question of a finite neutrino rest mass, searched for in theβ-decay spectrum of tritium and to problems in precision electron spectroscopy in general.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01294491
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    Paper (German National Licenses)
    Fulltext
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