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  • 29Si NMR  (1)
  • Hemolytic anemia  (1)
  • Inhibitory activity  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Hb Nottingham or α2β2 98 (FG5) Val→Gly in a Czech child (1994)
    Springer
    Annals of hematology 69 (1994), S. 93-95 
    Details
    ISSN: 1432-0584
    Keywords: Unstable hemoglobin ; Hb Nottingham ; Hemolytic anemia ; Splenectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a fourth case of Hb Nottingham [α2β2 98 (FG5) Val→Gly] observed in an 8-year-old girl in the Czech Republic with clinical and laboratory symptoms of severe hemolytic anemia. The unstable hemoglobin probably represents a de novo mutation, since the parents of the patient and the two siblings do not exhibit any hematological abnormalities. Splenectomy had a beneficial effect on the degree of hemolysis, as well as on the Hb level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01698489
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Leukocyte-derived inhibitory activity in patients with myelodysplastic syndrome (1987)
    Springer
    Annals of hematology 55 (1987), S. 165-171 
    Details
    ISSN: 1432-0584
    Keywords: Inhibitory activity ; Granulopoiesis ; Low-density cells ; Myelodysplastic syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Leukocyte-derived inhibitory activity inhibiting the entry of normal progenitor cells of granulocytes and macrophages (CFU-GM) into the S-phase of a cell cycle was investigated in 16 patients with different forms of myelodysplastic syndrome (MDS). The presence of this inhibitory activity was analysed in medium conditioned with low-density cells obtained from peripheral blood of MDS patients. The inhibition rate was measured by 3H-thymidine suicide technique with subsequent cultivation of pretreated cells in semisolid agar medium. Low-density cells from MDS patients of various types were studied: from the twelve patients with refractory anaemia (RA or RAS) only three were positive, one patient with chronic myelomonocytic leukaemia (CMML) was negative while one patient with refractory anaemia with excess of blasts (RAEB) and two patients with RAEB in transformation (RAEB-T) were positive with respect of the described test. In two patients with RA, who underwent a long-term investigation, the production of leukocyte-derived inhibitory activity preceded the development of disease into RAEB or RAEB-T. In five positive cases, supernatants were incubated with antiserum against human placental ferritin; with one exception, the inhibitory activity was neutralized.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320571
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Steric effects induced by solvent association. 29Si NMR chemical shifts in trimethylsiloxysteroids controlled by solvent accessible surface (1994)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 32 (1994), S. 394-398 
    Details
    ISSN: 0749-1581
    Keywords: Steric effects ; Solvent effects ; 29Si NMR ; Steroids ; Trimethylsilyl derivatives ; Steric shifts ; Solvent accessible surface ; Steric hindrance ; Hydrogen bond ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Chemical shifts of silicon-29 in 39 trimethylsiloxy derivatives of 5α- and 5β-androstanes reported here satisfy an empirical linear correlation with terms describing molecular geometry. The steric 29Si chemical shifts are controlled by association of the silyl ethers with the hydrogen bonding solvent. The chemical shifts measured in dilute solutions show a dependence on the surface of the oxygen atom accessible to the solvent for hydrogen bonding. The steric upfield shifts are due to steric hindrance to hydrogen bonding which itself produces downfield shifts.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260320704
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    Paper (German National Licenses)
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