Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Crohn's disease  (2)
  • Therapie  (2)
  • 3α-Hydroxysteroiddehydrogenase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Clinica Chimica Acta 137 (1984), S. 21-32 
    ISSN: 0009-8981
    Keywords: 3α-Hydroxysteroiddehydrogenase ; Bacterial diaphorase ; Bile acid and salt ; Bioluminescence ; Gas liquid chromatography ; Immobilized enzyme ; Luciferase
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 69 (1991), S. 981-987 
    ISSN: 1432-1440
    Keywords: Inflammatory bowel diseases ; Inflammatory mediators ; Crohn's disease ; Ulcerativecolitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases (IBD) of unknown etiology. They are characterized by an activation of intestinal mononuclear cells. Cytokines play a crucial role in the regulation of the functions of these cells. An increased synthesis of the cytokines interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factorα (TNFα), which are primarily synthesized by activated monocytes/macrophages has been described in patients with IBD. The synthesis of interleukin-2 (IL-2) and of interferonγ (IFNγ), which are produced by lymphocytes, on the other hand, has been found to be decreased. The published data are, however, not quite consistent. In patients with IBD there is not only a stimulation of the local cytokine production in the gut. The blood levels and the synthesis of the cytokines IL-1, IL-6 and TNFα by peripheral blood mononuclear cells are also increased, in particular in patients with Crohn's disease. Drugs, which are commonly used for the treatment of IBD impair the synthesis of these cytokines in monocytes/macrophages.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 38 (1997), S. 582-589 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Colitis ulcerosa ; Therapie ; M. Crohn ; Therapie ; Immunsuppression ; chronische Darmerkrankungen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Der immunsuppressiven Therapie kommt bei chronischen Darmerkrankungen große Bedeutung zu, insbesondere dort, wo die Standardtherapie nicht den gewünschten Erfolg zeigt. Als Therapie der ersten Wahl gelten bei Colitis ulcerosa 5-Aminosalizylsäure-freisetzende Medikamente, bei Morbus Crohn Kortikosteroide. Innerhalb der Gruppe immunsuppressiver Präparate gibt es erhebliche Wirkungsunterschiede. Darüber hinaus ist die Immunsuppression auch mit ernstzunehmenden Nebenwirkungen belastet. Über den Stellenwert der Immunsuppression als Ergänzung, mögliche oder bei Unverträglichkeit notwendige Substitution der Standardtherapien von Colitis ulcerosa und Morbus Crohn wird hier eingehend referiert. Auch die Behandlung dieser Erkrankungen in der Schwangerschaft wird dabei erläutert.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Internist 40 (1999), S. 1288-1299 
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Morbus Crohn ; Colitis ulcerosa ; Therapie ; Komplikationen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zum Thema Trotz der Fortschritte in der Erfassung genetischer Grundlagen und im Verständnis der Mechanismen der Entzündungsreaktion in der intestinalen Mukosa ist die Behandlung der chronisch entzündlichen Darmerkrankungen auch am Ende dieses Jahrhunderts noch eine symptomatische Therapie, die keine Heilung, sondern nur eine Behandlung der Schübe der Erkrankung und den Versuch einer Erhaltung einer einmal erreichten Remission beinhaltet. Eine Ausnahme bildet die chirurgische Therapie der Colitis ulcerosa, die die Krankheit heilt, aber mit dem Verlust des Kolons und der Reservoirfunktion im Rektum ihrerseits wieder Beschwerden hervorrufen kann. Angesicht dieser Situation ist ein optimales Verhältnis von Wirkung und Nebenwirkungen besonders wichtig. Einer Verbesserung dieses Verhältnisses waren viele Bemühungen der letzten Jahre gewidmet.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 38 (1993), S. 1638-1644 
    ISSN: 1573-2568
    Keywords: inflammatory bowel disease ; Crohn's disease ; ulcerative colitis ; PMN-elastase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract PMN-elastase is a proteinase released by activated neutrophils. PMN-elastase was determined in two independent populations with inflammatory bowel disease. In an unselected population of 70 consecutive patients with Crohn's disease and 24 patients with ulcerative colitis with different degrees of disease activity plasma PMN-elastase levels were statistically significantly higher in patients with active than in patients with inactive disease [Crohn's disease: 80.5±33.2 ng/ml vs 60.1±24.6 ng/ml (means±sd),P=0.0017; ulcerative colitis: 98.2±54.9 ng/ml vs 59.2±16.8 ng/ml,P=0.026]. PMN-elastase levels in feces were also higher in patients with active Crohn's disease (23.6±15.3 ng/g vs 13.6±12.5 ng/g,P=0.0021) and active ulcerative colitis (46.5±60.5 ng/g vs 20.2±25.0 ng/g,P=0.46), but the difference reached significance only in Crohn's disease. Correlation of disease activity and PMN-elastase in individual patients showed a statistically significant correlation between plasma and fecal elastase concentrations and disease activity in ulcerative colitis (plasma:r=0.72,P〈0.001; feces:r=0.423,P〈0.001) but not fecal elastase concentrations (r=0.0083,P=0.485) correlated significantly with disease activity. Plasma PMN-elastase correlated weakly with fecal PMN-elastase levels in Crohn's disease (r=0.431,P〈0.01) and in ulcerative colitis (r=0.515,P=0.05). In 28 patients with highly active Crohn's disease [median severity activity index (SAI) 203] and 11 patients with highly active ulcerative colitis [median Rachmilewitz index (RI) 14] studied before and four weeks after steroid therapy, treatment lowered the median SAI to 140 and the median RI to 4.5. Mean plasma elastase concentrations decreased concomitantly from 83±44.9 ng/ml to 61.8±25.8 (P=0.0035) in patients with Crohn's disease and from 110±49.5 to 71.6±28.8 ng/ml (P=0.0069) in patients with ulcerative colitis. In conclusion, there is a release of PMN-elastase in active IBD, which can be detected in plasma as well as in feces. Plasma elastase levels reflect disease activity in patients with IBD. The variation of the data and the large overlap between different groups, however, strongly reduce the clinical value.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...