ISSN:
0009-2940
Keywords:
Gold complexes
;
Palladium complexes
;
Platinum complexes
;
Rhodium complexes
;
Iridium complexes
;
3′-Azido-3′-deoxythymidine
;
3′-Isocyano-3′-deoxythymidine
;
Anti-HIV
;
Antiinflammatory activity
;
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Metal Complexes of Biologically Important Ligands, LX. - Metal Complexes of 3′-Azido-3′-deoxythymidine (AZT) and 3′-Isocyano-3′-deoxythymidineMetal complexes of N-3-deprotonated 3′-azido-3′-deoxythymidine (AZT - H+), (AZT - H+)AuPR3 (R = Me, Et, Ph) (2, 3, 4), trans-(AZT - H+)2Pd(NH3)2 (5), [(n-Bu3P)(AZT - H+) M(μ-Cl)2M(AZT - H+)(n-Bu3P)] (M = Pd, Pt) (6, 7), trans-(Ph3P)2Pd(AZT - H+)2 (8), cis-(Ph3P)2Pt(AZT - H+)(Cl) (9), and complexes of 3′-isocyano-3′-deoxythymidine (L), (Et3P)(L)- PdCl, (11), (12), (n-Bu3P)(L)PtCl2 (13), [(Ph3P)2(L)PtCl](BF4) (14), (η5-C5Me5)(L)RhCl2 (15), and (η5-C5Me5)(L)IrCl2 (16) have been prepared and characterized by IR and NMR spectra, 2 by X-ray crystallography. 2, 4, and 9 show an anti-HIV activity very similar to AZT; 2 exhibits antiinflammatory activity.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19911240710
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