Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 3-PPP  (1)
  • 35.80  (1)
  • Anti-insulin antibodies  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Dopamine receptor agonistic and antagonistic effects of 3-PPP enantiomers (1983)
    Springer
    Psychopharmacology 81 (1983), S. 199-207 
    Details
    ISSN: 1432-2072
    Keywords: Dopamine agonists ; Autoreceptors ; 3-PPP ; Neuroleptics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers showed weak DA agonistic activity, and (-)-3-PPP some DA antagonistic effect on DA-stimulated adenylate cyclase activity. Both enantiomers in low doses had a similar profile in vivo: Inhibition of locomotor activity of mice and rats, induction of contralateral circling behaviour in 6-hydroxy-DA-lesioned rats and an emetic effect in dogs. At higher doses, differential effects of the enantiomers were found: (+)-3-PPP induced hyperactivity, weak stereotyped behaviour and ipsilateral circling in hemitransected rats. (-)-3-PPP had depressant effects in high doses, inhibited d-amphetamine-induced hyperactivity and d-amphetamine-, methylphenidate- and apomorphine-induced stereotyped licking/biting in rats and antagonized apomorphine-induced emesis in dogs. However, (+)-3-PPP also showed a weak antagonistic activity against d-amphetamine-induced hyperactivity and d-amphetamine-and apomorphine-induced stereotypy in rats and inhibited apomorphine-induced emesis in dogs. It is suggested that both enantiomers have significant effects on postsynaptic DA receptors in high doses: (-)-3-PPP with weak antagonistic activity in some test models and (+)-3-PPP with agonistic and antagonistic effect. Since these effects of (+)-3-PPP were of low intensity at high doses, (+)-3-PPP may be a partial DA agonist at postsynaptic receptors in high doses. Interaction experiments with neuroleptics indicated that only (-)-3-PPP significantly increased the antistereotypic effect of neuroleptics in rats. Therefore, the proposed DA autoreceptor stimulation is possibly unrelated to the neuroleptic potentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427262
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    An experiment concept to measure stratospheric trace constituents by laser heterodyne spectroscopy (1980)
    Springer
    Applied physics 23 (1980), S. 47-56 
    Details
    ISSN: 1432-0630
    Keywords: 89.60 ; 35.80 ; 06.70
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Laser heterodyne spectroscopy (LHS) techniques with semiconductor laser local oscillators (LO) in the 3–30 μm range have the potential to measure radical gas species in the stratosphere. The goal of this experiment is to measure radical gases from Spacelab, including ClO, ClONO2, HO2, H2O2, N2O5, and HOCl in solar occulation with vertical resolution ≦2km and vertical range from 10 to 70 km. Sensitivity analyses have been performed on ClO and O3 to determine design criteria for the LHS instrument. Results show that O3 and ClO vertical profiles can be measured with an accuracy ≧95% and ≧80%, respectively, over the total profile. These accuracies require the LO to maintain the following characteristics: frequency stability (Δf w≦20 MHz), single-mode power (P LO≧500 μW), and minimum frequency drift (≦5 MHz). Laboratory heterodyne measurements performed with semiconductor lasers generated the same shot-noise photocurrent as CO2 lasers, for comparable single-mode power. “Excess-noise” regions were identified, but could be wavelength controlled by fine control of operating temperature and injection current. Doppler-shift effects and limited solar occultation measurement times due to Spacelab orbits should pose minimum mission constraints on the experiment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00899570
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Anti-insulin antibodies may cause hypoglycaemia following pancreas transplantation (1998)
    Springer
    Acta diabetologica 35 (1998), S. 172-175 
    Details
    ISSN: 1432-5233
    Keywords: Key words Pancreas transplant ; Hypoglycaemia ; Anti-insulin antibodies ; Diabetes mellitus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Some pancreas transplantation (PTX) recipients experience hypoglycaemia after transplant. We studied the incidence and pattern of hypoglycaemic symptoms following PTX and later studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycaemia following PTX. In a survey of 54 PTX recipients who were 2 to 33 months post-transplant, 29 reported symptoms of hypoglycaemia at any time following their transplant. Of 12 patients who tried to document their blood glucose during any episode, 5 had a blood glucose less than 3.3 mmol/l, and another 5 documented a blood glucose from between 3.33 and 3.88 mmol/l. The patients reporting symptoms were less likely to be insulin resistant with longer time post-PTX, lower body mass index (BMI), and on lower doses of prednisone. Later, 12 patients with established, repeated episodes of hypoglycaemia following PTX were case-matched to PTX recipients without hypoglycaemic symptoms. Fasting glucose, free and total immunoreactive insulin (IRI), C-peptide, proinsulin and glucagon were measured following a 4 h Sustacal challenge. The hypoglycaemic group was further divided into those whose glucose rose after Sustacal (Hypo-High) and those whose blood glucose did not rise from baseline concentration (Hypo-Flat). The Hypo-High subgroup had a lower fasting free/total IRI ratio in addition to a greater increase in blood glucose after Sustacal compared with either Hypo-Flat or non-hypoglycaemic transplant recipients. The low free/total insulin ratio and hyperglycaemic response to Sustacal are consistent with the presence of anti-insulin antibodies, an established cause of hypoglycaemia. In summary, documented hypoglycaemia, while uncommon, may occur and be significant following PTX. Anti-insulin antibodies may be one of the many factors contributing to hypoglycaemia in this population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005920050127
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...