ISSN:
1573-904X
Keywords:
lovastatin
;
simvastatin
;
sustained-release dosage forms
;
3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase inhibitors
;
dog
;
humans
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Seven sustained/controlled-release dosage forms were designed for gastrointestinal delivery of lovastatin or simvastatin, two potent HMG-CoA reductase inhibitors for the treatment of hypercholesterolemia. The in vivo performance of these formulations was evaluated in dogs and healthy volunteers in terms of the cholesterol lowering efficacy and/or systemic concentrations of HMG-CoA reductase inhibitors. Results from the present and previous studies suggest that, through the controlled release of HMG-CoA reductase inhibitors, sustained lower plasma concentrations of HMG-CoA reductase inhibitors may result in an equal or better therapeutic efficacy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018997308946
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