ISSN:
1573-2568
Keywords:
31P nuclear magnetic resonance spectroscopy
;
portacaval shunt
;
liver regeneration
;
intracellular pH
;
fructose
;
cyclosporine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The changes in fructose-1-phosphate (F-1-P), intracellular pH, and ATP content of the liver after a fructose challenge were investigated noninvasivelyin vivo using phosphorus-31 nuclear magnetic resonance spectroscopy of dog liver four days after a portacaval shunt (PCS) with or without portal venous infusion of cyclosporin (CsA). The F-1-P metabolism was slower in PCS dogs (N=2) as compared to either the normal (N=2) or PCS+CsA-treated dogs (N=3) (P〈0.05). The intracellular pH temporarily decreased from 7.3±0.05 to 7.0±0.05 during the fructose challenge. The regenerative indexes were increased in the PCS+CsA group (P〈0.01). These data obtainedin vivo using31P-NMR spectroscopy in the liver following a portacaval shunt, suggest that : (1) the energy status of the liver and the metabolic response to fructose are reduced in PCS compared to normal animals and (2) CsA treatment enhances the regenerative response of the liver and prevents the reduction in hepatic function associated with portacaval shunting.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01297039
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