Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 62 (1984), S. 675-688 
    ISSN: 1432-1440
    Keywords: Immunohistology ; Skin alterations ; Graft-versus-host disease ; Bone marrow transplantation ; Langerhans cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin biopsies of 26 patients with leukemia and seven patients with aplastic anemia were investigated before and at different stages after allogeneic bone marrow transplantation (BMT) to establish the immunological criteria which distinguish skin alterations during normal reconstitution from dermal lesions mediated by graft-versushost disease (GvHD). Of the 33 patients studied 27 presented with clinically diagnosed acute and/or chronic GvHD, one patient died of bone marrow rejection. Immunohistological analysis of the respective skin biopsies with selected monoclonal antibodies against human leukocyte antigens (HLA) and differentiation antigens of the lympho-hematopoietic cells revealed low dermal mononuclear cell counts with phenotypically normal constituents in five cases with uncomplicated reconstitution post-grafting. In contrast, increased dermal cellular infiltrates predominantly consisting of Lyt 3+, OKT 8+ T-lymphocytes, as well as of a large number of Ia-like (immune response associated = HLA-D) determinant+ monocytes/macrophages were observed in all patients with active acute/chronic GvH reactivity. As sign of activation simultaneous expression of HLA-D region products was also found on a subset of the invading OKT 8+ T-lymphocytes. Progression of GvHD was associated with additional surface staining of keratinocytes for Ia-like determinants. Loss of Ia-like determinant+, OKT 6+ dentritic epithelial cells in all leukemic patients, as well as in patients with aplastic anemia with or without GvHD suggested damage of Langerhans cells due to the previous radiotherapy and/or specific immunological destruction. In patients with fatal outcome of GvHD prolonged reduction of these dentritic epithelial cells seemed to be indicative of impaired immune reconstitution or bone marrow dysfunction. Thus immunopathological features of skin GvHR may enable early recognition and prognostic evaluation of this disease possibly allowing more effective therapy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Gerontologie + Geriatrie 33 (2000), S. S085 
    ISSN: 0044-281X
    Keywords: Key words Aging – communication – everyday competence – intervention – health – living environments ; Schlüsselwörter Alltagskompetenz – Altern – Gesundheit – Intervention – Kommunikation – Wohnen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dieser Beitrag nimmt seinen Ausgang davon, daß die Interventionsgerontologie heute ein sehr breites Spektrum an Einflußformen auf normales Altern wie Altern mit Kompetenzeinbußen bereitstellt. Als zweiter Ausgangspunkt wird die These aufgestellt, daß die Interventionsgerontologie in Zukunft in noch stärkerer Weise, als dies bereits heute der Fall ist, Alternsverläufe verändern kann und wird. Im weiteren werden der Stellenwert der interventionsgerontologischen Forschung heute detailliert dargelegt und dabei vor allem die heute existierende Verknüpfung mit grundlagenwissenschaftlichen Befunden, die zugrundeliegende kontextuelle Sicht des Alterns, die interdisziplinäre Orientierung sowie der erreichte Methodenstandard herausgestellt. Sodann wird das in der Zukunft zu erwartende Potential der Interventionsgerontologie an drei Bereichen illustriert: 1. Gesundheit und Alltagskompetenz, 2. Wohnen und 3. Kommunikation.
    Notes: Summary This paper starts with the insight that today's intervention gerontology provides a very broad scope of strategies with impact on the course of normal aging as well as aging with competence losses. Also, it is assumed that this impact of intervention gerontology will grow even further in the future. In the following, current intervention gerontology research is discusses by particularly highlighting its connection with basic gerontology findings, the contextual view of aging, the interdisciplinary orientation, and the methodological standard. With respect to the potential of gero-intervention in the future, three prototypical domains are considered: (1) health and everyday competence, (2) living environments, and (3) communication.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 16 (1990), S. 229-230 
    ISSN: 1434-6079
    Keywords: 52.40.Mj ; 34.50.Bw
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The energy loss of heavy ions with an energy of 1.4 MeV/u in a hydrogen plasma has been measured. A 20 cm longz-pinch has been used as plasma target. Our data show a strong enhancement of the stopping power of the plasma compared to that of a cold gas with equal density. The results completely confirm the predictions of the standard stopping power model.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...