ISSN:
1573-5001
Keywords:
3D COSY-J
;
H−P coupling constants
;
Oligonucleotides
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Summary A frequency-time domain 3D NMR technique has been developed for measurement of heteronuclear coupling constants in oligonucleotides employing a combination of COSY andJ-resolved techniques. The method employs frequency-selective excitation to generate the ω1 axis and 2D FT to generate the ω2 and ω3 axes. The procedure yields high resolution, especially along the ω1 axis. The technique is demonstrated on a dinucleotide.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01877231
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