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  • 3H-N-propyl-norapomorphine  (1)
  • Analytical Chemistry and Spectroscopy  (1)
  • Climbing behavior  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effects of discriminant and non-discriminant dopamine antagonists on in vivo accumulation of 3H-N-propyl-norapomorphine in mouse striatum and tuberculum olfactorium (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 329 (1985), S. 117-122 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Dopamine receptors ; 3H-N-propyl-norapomorphine ; Discriminant dopamine antagonists ; Striatum ; Tuberculum olfactorium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The in vivo accumulation of 3H-N-propyl norapomorphine in mouse striatum and tuberculum olfactorium and its inhibition by a series of classical neuroleptics and discriminant benzamide derivatives previously identified in behavioural and radioligand experiments has been studied. The ID50 values in the two brain areas did not significantly differ with any studied compound. In addition the regional distribution of a discriminant compound related to sulpiride and administered in tritiated form to rats was rather homogeneous. These data do not indicate a preferential accumulation of these compounds in limbic as opposed to striatal areas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00501199
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  • 2
    Digitale Medien
    Digitale Medien
    Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum (1976)
    Springer
    Psychopharmacology 50 (1976), S. 1-6 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Climbing behavior ; Dopamine receptors ; Apomorphine ; Antipsychotics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship. This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens. The relative efficacy of various agonists and antagonists of dopamine receptors have been determined on this test. It appears that this stereotyped behavior might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00634146
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  • 3
    Digitale Medien
    Digitale Medien
    The functional relationship scan in tandem mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 23 (1988), S. 579-584 
    Details
    ISSN: 0030-493X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A type of tandem mass spectrometric scan is described in which m1 +, m2 + and m3, defined in terms of the process m1 + → m2 + + m3, are all varied while maintaining some prescribed relationship between them. The scan can be viewed as a variant upon the neutral loss scan in which the constant mass difference between parent and daughter ion masses is replaced by some other functional relationship. Specific examples of this scan are provided in two simple applications: (i) symmetrical proton-bound dimers are recognized using the functional scan m2 = (m1 + 1)/2; and (ii) symmetrical Diels-Alder adducts comprised of diene and dienophile of equal masses are recognized in mixtures using the scan function m2 = (1/2)m1.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/oms.1210230805
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