ISSN:
1432-2072
Schlagwort(e):
Climbing behavior
;
Dopamine receptors
;
Apomorphine
;
Antipsychotics
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship. This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens. The relative efficacy of various agonists and antagonists of dopamine receptors have been determined on this test. It appears that this stereotyped behavior might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00634146
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