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  • 1
    Electronic Resource
    Electronic Resource
    Effects of discriminant and non-discriminant dopamine antagonists on in vivo accumulation of 3H-N-propyl-norapomorphine in mouse striatum and tuberculum olfactorium (1985)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 329 (1985), S. 117-122 
    Details
    ISSN: 1432-1912
    Keywords: Dopamine receptors ; 3H-N-propyl-norapomorphine ; Discriminant dopamine antagonists ; Striatum ; Tuberculum olfactorium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The in vivo accumulation of 3H-N-propyl norapomorphine in mouse striatum and tuberculum olfactorium and its inhibition by a series of classical neuroleptics and discriminant benzamide derivatives previously identified in behavioural and radioligand experiments has been studied. The ID50 values in the two brain areas did not significantly differ with any studied compound. In addition the regional distribution of a discriminant compound related to sulpiride and administered in tritiated form to rats was rather homogeneous. These data do not indicate a preferential accumulation of these compounds in limbic as opposed to striatal areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501199
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum (1976)
    Springer
    Psychopharmacology 50 (1976), S. 1-6 
    Details
    ISSN: 1432-2072
    Keywords: Climbing behavior ; Dopamine receptors ; Apomorphine ; Antipsychotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship. This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens. The relative efficacy of various agonists and antagonists of dopamine receptors have been determined on this test. It appears that this stereotyped behavior might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634146
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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