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  • 3H-Telenzepine binding  (1)
  • Polymer and Materials Science  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacological characterization of muscarine receptors of PC 12 (rat phaeochromocytoma) cells (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 158-164 
    Details
    ISSN: 1432-1912
    Keywords: PC 12 cells ; Muscarnne receptors ; 3H-Noradrenaline release ; 3H-Telenzepine binding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The muscarinereceptors of PC12 (rat phaeochromocytoma) cells were studied in functional and binding experiments. The catecholamine stores of PC 12 cells were labelled by incubation of the cells with tritiated noradrenaline. Muscarinic agonists elicited concentration-dependent release of tritium which consisted overwhelmingly of unchanged 3H-noradrenaline. The rank order of potency was: oxotremorine 〉 acetylcholine 〉 muscarine = methacholine 〉 carbachol 〉 bethanechol. The release evoked by carbachol (0.1 mmol/l) was inhibited with high potency by the M1-selective antagonist telenzepine (pK i = 8.82), with intermediate potency by pirenzepine (pK i = 7.00) and with low potency by the M2-selective antagonist AF-DX 116 (pK i = 5.74). The binding of 3H-N-methylscopolamine to PC 12 membranes was inhibited by various non-selective and subtype-selective muscarinic antagonists with the following rank order of potency: telenzepine = atropine 〉 4-DAMP 〉 dicyclomine 〉 pirenzepine 〉 HHSiD 〉 AF-DX 116. A similar rank order was obtained for the inhibition by these compounds of 3H-telenzepine binding to Mi-receptors in membranes of the cerebral cortex of the guinea pig. The Hill coefficients for inhibition of 3H-N-methylscopolamine binding (to PC 12 membranes) by pirenzepine, telenzepine and AF-DX 116 were below unity. Specific binding of both 3H-telenzepine and 3H-N-methylscopolamine to muscarine receptors of PC 12 membranes was saturable and of high affinity; the maximal number of binding sites was higher for 3H-N-methylscopolamine than for 3H-telenzepine (calculated for the active (+)enantiomer). PC 12 cells are presumably endowed with more than one subtype of muscarine receptors. The predominant receptor is an “atypical” receptor; it is neither a M2- nor a M3-receptor, and in spite of the high affinity of telenzepine for this receptor it is probably also not an M1-receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169725
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    CEMS and AES Investigations on Iron Silicides (1996)
    Chichester [u.a.] : Wiley-Blackwell
    Surface and Interface Analysis 24 (1996), S. 411-415 
    Details
    ISSN: 0142-2421
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Thin layers of iron silicides produced by ion implantation were investigated by 57Fe conversion electron Mössbauer spectroscopy and Auger electron spectroscopy. The Mössbauer hyperfine parameters were calculated and compared with results obtained at crystalline layers to determine the phases formed. It was found that, depending on the implantation conditions, the phases α- and β-FeSi2, ε-FeSi or mixtures of them are formed. Auger electron spectroscopy was used to analyse the depth distribution of the elements in the layer. The iron concentrations necessary, according to the equilibrium phase diagram, to form the compounds mentioned above were not reached as a result of the implantation. Therefore, the formation of precipitates is concluded. Furthermore, it was found that the Si KLL Auger peak is very sensitive to silicide bonding. Its energy shift can be used as an indicator for silicide formation.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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