ISSN:
1573-0646
Keywords:
anthracycline
;
4′-o-tetrahydropyranyl adriamycin
;
phase I study
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The phase I study of a new anthracycline, 4′-o-tetrahydropyranyl adriamycin, was performed. A dose limiting factor was leukopenia while thrombocytopenia was less frequent and a maximum tolerated dose was determined as 54 mg/m2. Mild gastrointestinal toxicities including anorexia, nausea and vomiting occurred in about half of the patients, while very minimal alopecia was seen in only one patient. A recommended dose for phase II study was established: 40 mg/m2 at 3-week intervals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00172076
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