ISSN:
0947-3440
Keywords:
HMG-CoA reductase inhibitors
;
3-Indolylheptanoates and -acetates
;
4-Chromanylheptanoates and -acetates
;
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The indole (1) and chroman analogs (2) of mevinolin and their 6S diastereomers 15c and 25d were synthesized in several steps starting with methyl (R)-3-[(tert-butyldimethylsilyl)oxy]-4-formylbutyrate (12) and 2-(indol-3-yl)ethanol (3) or 6-methoxychroman-4-one (16), respectively. Compounds 1 and 2 inhibited moderately the HMG-CoA reductase. The diastereomers 15c and 25d were shown to be inactive.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.1995199510263
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