ISSN:
1432-2072
Keywords:
Mass fragmentography
;
5-Hydroxyindole-3-acetic acid
;
4-Hydroxy-3-methoxyphenylacetic acid
;
4-Hydroxy-3-methoxyphenylethylene glycol
;
Cerebrospinal fluid
;
Brain
;
Urine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract A mass fragmentographic method for the simultaneous determination of 4-hydroxy-3-methoxyphenylacetic acid (HVA), 4-hydroxy-3-methoxyphenylethylene glycol (MOPEG), and 5-hydroxyindole-3-acetic acid (5-HIAA) was described. Deuterated analogues of the compounds were used as internal standards. The specificity was proved by multiple ion analysis. The experimental error was below 7% when applied to the analysis of human lumbar cerebrospinal fluid, urine, or rat brain tissue. In cerebrospinal fluid the major part of the monoamine metabolites occurred in the free form. In rat brain and human urine considerable amounts of conjugated HVA was found.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00423253
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