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  • 5/6 Nephrectomy  (1)
  • BBGKY hierarchy  (1)
  • TGFβ1 mRNA  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Phospholipase A2 mRNA in remnant kidney is modulated by dietary alpha-tocopherol (1999)
    Springer
    Clinical and experimental nephrology 3 (1999), S. 250-253 
    Details
    ISSN: 1437-7799
    Keywords: Key wordsα-Tocopherol ; 5/6 Nephrectomy ; Remnant ; Phospholipase A2 mRNA ; Activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. Glomerulosclerosis is a characteristic feature in the subtotal (5/6) nephrectomy, remnant kidney model in the rat. It is postulated that oxidative stress from this renal mass reduction may induce the glomerular and tubular injury leading eventually to glomerulosclerosis. In support of this line of reasoning, an antioxidant, α-tocopherol, has been recently demonstrated to prevent such injury. Because group IIA phospholipase A2 is upregulated in a variety of injuries including ischemic proximal tubular necrosis, we examined whether up-regulation of phospholipase A2 is associated with the initiation of injury leading to the glomerulosclerosis and whether α-tocopherol can modulate such activity. Methods. We set out to examine whether secretory group IIA phospholipase A2 (sPLA2) mRNA levels (Northern analysis) are increased in the remnant kidney and whether α-tocopherol has the capacity to modulate steady-state sPLA2 transcription levels. Results. Our data indicate that there is overproduction of sPLA2 message, and that α-tocopherol reduces the steady-state levels of sPLA2 mRNA in the remnant kidney. Total PLA2 enzymatic activity from homogenate of the remnant kidney strongly paralleled the Northern data. Conclusion. The results support a possible role of sPLA2 in the renal injury accompanying sudden reduction of renal mass and provide an additional rationale for the potential utility of α-tocopherol in modulating such injury in progressive renal disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570050043
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Indices of progression of IgA nephropathy are modulated by α-tocopherol in rats (2000)
    Springer
    Clinical and experimental nephrology 4 (2000), S. 187-192 
    Details
    ISSN: 1437-7799
    Keywords: Key words IgA nephropathy ; Rats ; Oxidative stress ; Malondialdehyde ; TGFβ1 mRNA ; α-Tocopherol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background. We have previously shown that α-tocopherol prevents oxidative stress in experimental IgA nephropathy (IgAN) when administered before or concurrent with the induction of IgAN. We now seek to determine whether α-tocopherol can ameliorate the disease after IgAN is established. Methods. Using the classic IgAN model, 25 male Lewis rats were sorted into five groups of five animals each: 4-week control, 4-week bovine gamma globulin (BGG) treatment, 6-week control, 6-week BGG treatment, and 6-week BGG treatment with α-tocopherol administration started after 4 weeks. Serum α-tocopherol concentrations, kidney and plasma malondialdehyde concentrations, and kidney transforming growth factor beta-1 (TGFβ1) mRNA were analyzed. Results.α-Tocopherol modulated IgAN after the disease was established in the 4-week BGG model, as indicated by the reduction in tissue oxidative stress, dampening of fibrogenic cytokine (TGFβ1), and abatement of proteinuria in α-tocopherol-treated animals compared with untreated rats. Conclusions. These results substantiate the anti-oxidant role of α-tocopherol in diminishing the indices associated with progression of experimental IgAN. The ability of α-tocopherol to reduce the progression of injury after establishment of the disease reflects the clinical situation, and thus holds promise for human therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s101570070020
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    m-Particle correlations in theN-particle McKean model (1989)
    Springer
    Journal of statistical physics 57 (1989), S. 267-288 
    Details
    ISSN: 1572-9613
    Keywords: BBGKY hierarchy ; correlations ; cluster expansion ; truncation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract This work extends the comparison between exact and approximate solutions of the McKean model to finite particle numbers. We derive the coupled linear equations of motion for them-body densities (BBGKY hierarchy) and the corresponding nonlinear equations for them-body correlation functions. We calculate the stable fixed points and the subspace admitting a probabilistic interpretation for both descriptions of the model. Neglecting higher correlations withm〉n, we obtain approximate solutions, which are compared to the exact one. In this way various truncation effects can be studied, such as the appearance of saddle points and unphysical trajectories. Finally, we linearize the truncated equations for the correlations about the stable fixed point, and calculate the relaxation times up toO(N −1).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01023643
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    Paper (German National Licenses)
    Fulltext
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