ISSN:
1432-198X
Keywords:
Key words Vitamin E
;
5/6 Nephrectomy rats
;
Oxidative stress
;
Malondialdehyde
;
Transforming growth factor β
;
Glomerulosclerotic index
;
Remnant kidney
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Previous studies have shown that reduction of renal mass in the rat remnant kidney model induces overproduction of transforming growth factor β1 (TGFβ1). We investigated whether an antioxidant, vitamin E, administered before the renal mass reduction, could prevent oxidative stress, reduce the overproduction of TGFβ1, and mitigate against the subsequent glomerulosclerosis. Our results revealed that the oxidative stress, as measured by the change in plasma malondialdehyde, is significantly reduced by prior vitamin E dietary supplementation. Finally, our data show that dietary vitamin E supplementation ameliorates the rise in TGFβ1 secondary to renal mass reduction and inhibits the glomerular sclerosis of the remnant kidney over the time course of this experiment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s004670050591
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