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  • 1
    Electronic Resource
    Electronic Resource
    Effects of three inhibitors of nitric oxide synthase on host resistance to bacterial infection (1996)
    Springer
    Inflammation research 45 (1996), S. 109-112 
    Details
    ISSN: 1420-908X
    Keywords: NG-nitro-L-arginine-methyl-ester (L-NAME) ; NG-monomethyl-L-arginine (L-NMMA) ; N-iminoethyl-L-ornithine (L-NIO) ; Septic shock ; Survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the effects of three nitric oxide synthase inhibitors on survival in a murine sepsis model.Design: Prospective randomized experimental trials.Setting: Laboratory.Subjects: Female Balb/c mice.Interventions:Escherichia coli (108 colony-formingunits/body) were injected into the peritoneal cavities of Balb/c mice. NG-nitro-L-arginine-methyl-ester, NG-monomethyl-L-arginine, or N-iminoethyl-L-ornithine was given at various concentrations, intraperitoneally, one hour before bacterial challenge.Measurements: One hundred and fifteen animals were observed for survival.Results: These inhibitors provided the mice no protection from the bacterial challenge. Notably, pretreatment with NG-nitro-L-arginine-methyl-ester (100 mg/kg i.p.) actually reduced survival time afterE. coli challenge.Conclusions: Inhibition of nitric oxide production improved neither the survival time nor rate in this murine sepsis model.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02265161
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Comparative drug elimination in man — Diphenylhydantoin and amobarbital (1975)
    Springer
    European journal of clinical pharmacology 9 (1975), S. 79-83 
    Details
    ISSN: 1432-1041
    Keywords: 5 ; 5-diphenylhydantoin ; 5-(p-hydroxyphenyl)-5-phenylhydantoin ; amobarbital ; drug elimination ; interindividual variation ; correlation studies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The concentration of 5,5-diphenylhydantoin (DPH) in serum was determined at selected time intervals in seven healthy male volunteers starting 10 h after an oral dose of 400 mg sodium DPH was given. The data were analyzed according to a one-compartment model assuming first-order kinetics. The mean serum half-life was 19.28 h±5.87 (SD). A positive correlation coefficient (r=0.84, p〈0.05) was found between the serum DPH half-life and the serum amobarbital half-life in the seven subjects. The urinary levels of free plus conjugated 5-(p-hydroxyphenyl)-5-phenylhydantoin were determined for 12 h periods over a minimum of two days following the 400 mg oral dose of sodium DPH. Subjects with a short DPH half-life tended to excrete in urine a greater amount ofp-HPPH as compared to subjects with a long DPH half-life. In the case of one subject, the urinary excretion ofp-HPPH plateaued five days after DPH administration and the apparent elimination half-life determined from thep-HPPH urinary excretion data was 19.16 h as compared to the value of 19.53 h calculated from the DPH serum levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00613433
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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