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  • 1
    Electronic Resource
    Electronic Resource
    Reduced coxsackie antibody titres in Type 1 (insulin-dependent) diabetic patients presenting during an outbreak of coxsackie B 3 and B 4 infection (1982)
    Springer
    Diabetologia 22 (1982), S. 426-429 
    Details
    ISSN: 1432-0428
    Keywords: Type 1 diabetes ; virus ; Coxsackie B 4 ; antibody titres
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The potential role of antecedent viral infection in the pathogenesis of Type 1 (insulin-dependent) diabetes was investigated by measuring antibody titres to several viruses in serum obtained at the time of diagnosis of diabetes. An outbreak of Coxsackie B 4 infection folio wed by a wave of Coxsackie B 3 and B 5 infections occurred in Seattle during the time viral serology was obtained in the diabetic patients. Antibody titres to Cocksackie B 5 and Influenza A and B viruses were comparable in diabetics and matched control subjects, but antibody titres to Cocksackie B 3 and B 4 were lower in the diabetics and a low antibody titre to Coxsackie B 3/B 4 was associated with a significantly increased relative risk of diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282584
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Treatment of isolated fat cells with trypsin inhibits the effects of insulin on incorporation of leucine into protein (1973)
    Springer
    Diabetologia 9 (1973), S. 422-425 
    Details
    ISSN: 1432-0428
    Keywords: Isolated fat cells ; insulin ; trypsin treatment ; plasma membranes ; amino acid incorporation ; amino acid mixture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Incorporation of 0.1 mM3H-leucine into protein by isolated fat cells, with pyruvate as the only extracellular carbohydrate, was stimulated by: a) insulin, 0.1–4 ng/ml, or b) a mixture of 19 amino acids, 0.05–5 mM. Treatment of fat cells with trypsin, under conditions known to reduce binding of insulin by their plasma membranes, abolished stimulation of incorporation by the hormone but not by the amino acid mixture. These results imply that the actions of insulin on incorporation of amino acids into protein are initiated by interaction with plasma membranes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01239439
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of adrenalectomy on 8-OH-DPAT induced hypothermia in mice (1999)
    Springer
    Psychopharmacology 142 (1999), S. 73-77 
    Details
    ISSN: 1432-2072
    Keywords: Key words Mice ; 5-HT ; Somatodendritic 5-HT1A receptor ; 8-OH-DPAT ; Hypothermia ; Adrenalectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Complex interactions exist between the hypothalamic-pituitary-adrenal (HPA) axis and the serotonergic system, and it has been suggested that these interactions may be fundamental to the pathophysiology and treatment of depressive illnesses. It has previously been found that chronic administration of corticosterone leads to adrenal suppression and an attenuation of somatodendritic 5-HT1A receptor function. Adrenalectomy (ADX) has been shown to cause an increase in postsynaptic 5-HT1A receptor numbers and possibly function. However, other reports have suggested that ADX does not alter somatodendritic 5-HT1A receptor mRNA or binding, though little is known of the effect of ADX on the function of somatodendritic 5-HT1A receptors. This study investigated the effect of markedly reducing corticosterone levels by ADX on 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT)-induced hypothermia in mice, an in vivo model of somatodendritic 5-HT1A receptor function. The degree of 8-OH-DPAT-induced hypothermia did not differ between control, sham, and ADX animals 14 days post operatively. Although repeated administration of corticosterone attenuates somatodendritic 5-HT1A receptor function, these data demonstrate that lowering of corticosteroid levels by ADX have no effect. This suggests that the effects of repeated corticosterone administration is not mediated by a secondary adrenal suppression. The difference in the effects of ADX on somatodendritic as opposed to postsynaptic 5-HT1A receptors may reflect the differential expression of corticosteroid receptor subtypes at postsynaptic and somatodendritic sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050864
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    Paper (German National Licenses)
    Fulltext
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