ISSN:
1432-2072
Keywords:
Dependence
;
Addiction
;
Drug abuse
;
Craving
;
Relapse
;
Tolerance
;
Sensitization
;
Withdrawal
;
Opponent process theories
;
Subjective
;
Discriminative effects
;
Reinforcement
;
Habit
;
Neural systems
;
Psychomotor stimulants
;
Amphetamine
;
Cocaine
;
Oppiates
;
Alcohol
;
Nicotine
;
Hallucinogens
;
Amygdala
;
Stratum
;
Nucleus accumbens
;
Dopamine
;
5-HT
;
Cerebral cortex
;
Functional neuroimaging
;
PET
;
Transcription factors
;
Behavioural genetics
;
Strain-dependent effects
;
Quantitative trait loci
;
Individual differences
;
Risk factors
;
Personality and dependence
;
Biological markers of dependence
;
Co-morbidity
;
Schizophrenia
;
Depression
;
Pharmacological treatment for dependence
;
Psychosocial treatment of dependence
;
Sociology of dependence
;
Epidemiology of dependence
;
Animal models of dependence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract This article summarizes the main discussions at a meeting on the biological, social and clinical bases of drug addiction focused on contemporary topics in drug dependence. Four main domains are surveyed, reflecting the structure of the meeting: psychological and pharmacological factors; neurobiological substrates; risk factors (including a consideration of vulnerability from an environmental and genetic perspective); and clinical treatment. Among the topics discussed were tolerance, sensitization, withdrawal, craving and relapse; mechanisms of reinforcing actions of drugs at the behavioural, cognitive and neural levels; the role of subjective factors in drug dependence; approaches to the behavioural and molecular genetics of drug dependence; the use of functional neuroimaging; pharmaceutical and psychosocial strategies for treatment; epidemiological and sociological aspects of drug dependence. The survey takes into account the considerable disagreements and controversies arising from the discussions, but also reaches a degree of consensus in certain areas.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02246016
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