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  • 5-HT1B receptor  (1)
  • Satiety  (1)
  • Serotonin  (1)
  • Subsurface  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of industrial microbiology and biotechnology 4 (1989), S. 109-120 
    ISSN: 1476-5535
    Keywords: Ground water ; Biodegradation ; Hydrocarbon ; Adaptation ; Subsurface ; Creosote ; Microorganism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Summary The microbial ecology of pristine, slightly contaminated, and heavily contaminated subsurface materials, and four subsurface materials on the periphery of the plume at an abandoned creosote waste site was investigated. Except for the unsaturated zone of the heavily contaminated material, mineralization of glucose (13.5 ppb) indicated a metabolically active microflora in all subsurface materials. However, mineralization (〈40%) of naphthalene, phenanthrene, and 2-methylnaphthalene was observed in contaminated material and material from the periphery of the plume, but not in pristine material. Pentachlorophenol was mineralized in material from the periphery of the plume. Inorganic and organic nutrient amendments and changes in pH and temperature did not increase the extent of mineralization of the aromatic compounds. An array of organic compounds found in creosote were biotransformed in contaminated ground water; however some compounds were still detected after 7 months of incubation. The data suggest that the subsurface microflora in slightly and heavily contaminated subsurface materials and materials from the periphery of the plume has adapted to degrade many compounds found in creosote.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Key words CP-93 ; 129 ; Serotonin ; 5-HT1B receptor ; Parabrachial nucleus ; Paraventricular nucleus ; Feeding ; Satiety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Unilateral infusion of the selective 5-HT1B agonist, CP-93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl) pyrrolo[3,2-b]pyrid-5-one) into the parabrachial nucleus (PBN) of the pons reduced food consumption by rats. The hypophagia was dose-related (ED50 ≈ 1 nmol) and associated with fewer observations of feeding and more periods of inactivity. Water intake, grooming and exploratory activity were unaffected. CP-93,129 also decreased food intake when injected into the hypothalamic paraventricular nucleus, but this action was 50-fold less potent than administration into the PBN. Autoradiography demonstrated 5-HT1B sites in the PBN; this binding was displaced by CP-93,129. The results implicate parabrachial 5-HT1B receptors in mediating serotonergic enhancement of satiation.
    Type of Medium: Electronic Resource
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