Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Inorganic Chemistry  (2)
  • 5-HT1D receptor  (1)
  • Aflatoxin B1  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Inhibition of noradrenaline release from the sympathetic nerves of the human saphenous vein via presynaptic 5-HT receptors similar to the 5-HT1D subtype (1990)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 342 (1990), S. 371-377 
    Details
    ISSN: 1432-1912
    Keywords: Noradrenaline release ; Serotonin receptors ; 5-HT1D receptor ; Presynaptic receptors ; Human saphenous vein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The human saphenous vein preincubated with [3H]noradrenaline was used to determine the pharmacological properties of the release-inhibiting presynaptic serotonin (5-HT) receptor on the sympathetic nerves. The overflow of tritium evoked by transmural electrical stimulation (2 Hz) was concentration-dependently inhibited by drugs known to stimulate 5-HT receptors in the following rank order: oxymetazoline ≥ 5-HT ≥ 5-carboxamidotryptamine = 5-methoxytryptamine = sumatriptan 〉 tryptamine 〉 N,N(CH3)2-5-HT = yohimbine = 8-hydroxy-2-(di-n-propylamino)-tetraline. The potencies of these agonists in inhibiting overflow were significantly correlated with their affinities for 5-HT1B and 5-HT1D binding sites, but not with those for 5-HT1A or 5-HT1C binding sites. 5-Aminotryptamine, methysergide, ipsapirone, cyanopindolol, SDZ 21009 and metergoline dit not produce a significant inhibition. Metitepine and methysergide antagonized the inhibitory effect of 5-HT, whereas spiroxatrine, propranolol, ketanserin and ICS 205-930 did not. These data exclude the idea that the inhibitory presynaptic 5-HT receptor on the sympathetic nerves belongs to the 5-HT2 and 5-HT3 receptor class; the pattern of agonist potencies suggests that the receptor is very similar to the 5-HT1D receptor subtype.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169451
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens (1986)
    Springer
    Journal of cancer research and clinical oncology 112 (1986), S. 85-91 
    Details
    ISSN: 1432-1335
    Keywords: Chemical carcinogenesis ; Mechanism of action ; Quantitative risk assessment ; Genotoxicity ; Dose-response relationship ; Aflatoxin B1 ; Formaldehyde ; Vinyl chloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Investigation of covalent DNA binding in vivo provided evidence for whether a test substance can be activated to metabolites able to reach and react with DNA in an intact organism. For a comparison of DNA binding potencies of various compounds tested under different conditions, a normalization of the DNA lesion with respect to the dose is useful. A covalent binding index, CBI=(μmol chemical bound per mol DNA nucleotide)/(mmol chemical administered per kg body weight) can be determined for each compound. Whether covalent DNA binding results in tumor formation is dependent upon additional factors specific to the cell type. Thus far, all compounds which bind covalently to liver DNA in vivo have also proven to be carcinogenic in a long-term study, although the liver was not necessarily the target organ for tumor growth. With appropriate techniques, DNA binding can be determined in a dose range which may be many orders of magnitude below the dose levels required for significant tumor induction in a long-term bioassay. Rat liver DNA binding was proportional to the dose of aflatoxin B1 after oral administration of a dose between 100 μg/kg and 1 ng/kg. The lowest dose was in the range of general human daily exposures. Demonstration of a lack of liver DNA binding (CBI〈0.1) in vivo for a carcinogenic, nonmutagenic compound is a strong indication for an indirect mechanism of carcinogenic action. Carcinogens of this class do not directly produce a change in gene structure or function but disturb a critical biochemical control mechanism, such as protection from oxygen radicals, control of cell division, etc. Ultimately, genetic changes are produced indirectly or accumulate from endogenous genotoxic agents. The question of why compounds which act via indirect mechanisms are more likely to exhibit a nonlinear range in the dose-response curve as opposed to the directly genotoxic agents or processes is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00404387
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Über die Existenzfähigkeit von Kupfermanganat(V) (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 327 (1964), S. 281-285 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The thermal decompositions of copper and barium manganate(VII) have been investigated in order to obtain manganates(V).
    Notes: Mit dem Ziel, Manganate(V) zu erhalten, wurde die thermische Zersetzung von Kupfermanganat(VII) und Bariummanganat(VII) untersucht.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19643270503
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Über Untersuchungen im System Kupfer/Mangan/Sauerstoff (1964)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 327 (1964), S. 275-280 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: The products of the thermal decompositions of mixed carbonates, oxalates, and nitrates of copper and manganese have been investigated chemically and by x-ray techniques.Similarly, the products of interactions between Cu2O, CuO or Cu and MnO, Mn2O3 or MnO2 are studied.The double oxide CuMnO2 has been prepared in the pure state.
    Notes: Die thermischen Zersetzungsprodukte gemeinsam gefällter Carbonate und Oxalate sowie gemeinsam eingedampfter Nitrate des Kupfers und Mangans wurden chemisch und röntgenographisch untersucht. Gemische aus Kupfer(I)-bzw. Kupfer(II)-oxid sowie Kupfer einerseits und Mangan(II)-, Mangan(III)- und Mangan(IV)-oxid andererseits wurden im Sauerstoff- und Stickstoffstrom sowie im Hochvakuum umgesetzt und ihre Reaktionsprodukte chemisch und röntgenographisch untersucht. Das Doppeloxid CuMnO2 wurde erstmalig rein dargestellt.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19643270502
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...