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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 136 (1998), S. 394-401 
    ISSN: 1432-2072
    Keywords: Key words Venlafaxine ; Olfactory bulbectomy ; β1-receptor binding ; 5-HT2 receptor binding ; 8-OH-DPAT
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study, the effect of chronic treatment with venlafaxine on β1 and 5-HT2 receptor populations was examined in the frontal cortex of olfactory bulbectomised (OB) and sham operated (SO) animals. The effect of these drugs on the behaviour of the animals on the elevated plus maze and the “open field” was also assessed. Removal of the bulbs resulted in a characteristic increase in locomotor activity in the OB animals in the “open field” which was reversed by chronic venlafaxine treatment. Venlafaxine produced a slight reduction in the number of open arm entries made by the OB animals although this failed to reach significance. Maximum change in temperature from baseline, following a single dose of 8-OH-DPAT (1.5 mg kg−1 SC), was used to assess the function of the 5-HT1A receptors. Chronic venlafaxine treatment had no effect on the hypothermic response to 8-OH-DPAT in the present study. A decrease in the affinity of β1-adrenoceptors was found following olfactory bulbectomy and this was normalised by treatment with venlafaxine. No bulbectomy-induced changes were evident 32 days post surgery in β1-adrenoceptor density; however, chronic treatment with venlafaxine significantly reduced the density of these receptors in the OB animals. Olfactory bulbectomy did not produce any changes in 5-HT2 receptor populations but venlafaxine administration significantly reduced the density of these receptors in both SO and OB animals. The findings of the present study further validate the usefulness of the OB as an animal model, for the detection of antidepressants from a wide variety of classes.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 37 (1997), S. 151-154 
    ISSN: 0021-9304
    Keywords: acrylic bone cement ; creep ; total joint replacement ; prosthesis ; biomaterials ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: It has been proposed that creep of acrylic bone cement may contribute to loosening of cemented total joint replacements. If true, it is important that factors affecting creep of bone cement are identified. The objective of this study was to evaluate the effect of an operator-controlled variable, injection time, on the creep behavior of acrylic bone cement. Results from this investigation showed that injection time significantly (p 〈 0.0001) influenced creep behavior of bone cement. “Delayed” injection time of acrylic bone cement increased creep by approximately 5 times in 24 h compared to specimens prepared according to standard injection procedures. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 37, 151-154, 1997.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 29 (1995), S. 495-501 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Compressive creep testing of cylindrical specimens machined from two commercial self-polymerizing acrylic bone cements demonstrated measurable creep strains with higher creep strains for the hand-mixed cement specimens compared to vacuum-mixed cement ones. The average creep strains of hand-mixed cement, after 6 h of constant load, ranged from 0.11° at 10.5 MPa to 14.0° at 50 MPa of applied stress. Vacuum mixing reduced the average creep strain to 6.7° after 6 h of applied stress at 50 MPa. There were no significant differences in the creep response between the two types of acrylic cements. The difference in creep resistance of the two cements was reduced after vacuum mixing (P = .013), which also significantly reduced the cement's internal porosity. © 1995 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 20 (1982), S. 91-96 
    ISSN: 0360-6384
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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