ISSN:
1432-1912
Keywords:
Migraine
;
Nitric oxide
;
Endothelium
;
5-HT2C Receptors
;
5-HT2B Receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The hypothesis that 5-hydroxytryptamine (5-HT) acting through 5-HT2c receptors is a key factor in the initiation of migraine has been re-evaluated in the light of recent basic and clinical scientific developments. The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache. Taken together the data bring new perspectives to the role of 5-HT acting through 5-HT2C (or closely similar) receptors in the initiation of migraine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00175026
Permalink
