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  • 1
    Electronic Resource
    Electronic Resource
    O-H stretching vibration in Fourier transform difference infrared spectra of bacteriorhodopsin
    Amsterdam : Elsevier
    FEBS Letters 287 (1991), S. 157-159 
    Details
    ISSN: 0014-5793
    Keywords: Bacteriorhodopsin ; Fourier transform infrared spectroscopy ; M intermediate ; O-H stretching vibration
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0014-5793(91)80039-6
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibitory effects of polyphenolic catechins from Chinese green tea on HIV reverse transcriptase activity (1994)
    Springer
    Journal of biomedical science 1 (1994), S. 163-166 
    Details
    ISSN: 1423-0127
    Keywords: Polyphenolic catechins ; HIV reverse transcriptase activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Three polyphenolic catechins, epigallocatechin (1), epicatechin-3-O-gallate (2) and epigallocatechin-3-O-gallate (3), were isolated from Chinese green tea, Ti-Kaun-Yin(Camellia sinensis) and demonstrated as a new class of human immunodeficiency virus-reverse transcriptase (HIV-RT) inhibitor. The concentrations required for 50% inhibition for the compounds (1), (2) and (3) were 7.80, 0.32 and 0.68 µM, respectively. The polyphenolic catechins with a galloyl group at the 3 position were potent inhibitors of HIV-RT. Kinetic analysis indicated that the polyphenolic catechins were competitive inhibitors with respect to the template-primer (rA)n(dT)12–18 and noncompetitive inhibitors to dTTP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253344
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Positron emission tomographic studies on aromatic L-amino acid decarboxylase activity in vivo for L-dopa and 5-hydroxy-L-tryptophan in the monkey brain (1993)
    Springer
    Journal of neural transmission 94 (1993), S. 127-135 
    Details
    ISSN: 1435-1463
    Keywords: 5-Hydroxy-L-(β-11 C)tryptophan ; L-(β-11 C)DOPA ; positron emission tomography ; aromatic amino acid decarboxylase ; monkeys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The regional brain kinetics following 5-hydroxy-L-(β-11 C)tryptophan and L-(β-11 C)DOPA intravenous injection was measured in twelve Rhesus monkeys using positron emission tomography (PET). The radiolabelled compounds were also injected together with various doses of unlabelled 5-hydroxy-L-tryptophan or L-DOPA. The radioactivity accumulated in the striatal region and the rate of increased utilization with time was calculated using a graphical method with back of the brain as a reference region. The rate constants for decarboxylation were 0.0070 ± 0.0007 (S. D) and 0.0121±0.0010min−1 for 5-hydroxy-L-(β-11C)tryptophan and L-(β-11 C)DOPA, respectively. After concomitant injection with unlabelled 5-hydroxy-L-tryptophan, the rate constant of 5-hydroxy-L-(β-11 C)tryptophan decreased dose-dependently and a 50 percent reduction was seen with a dose of about 4mg/kg of unlabelled compound. A decreased utilization rate of L-(β-11 C)DOPA was seen only after simultaneous injection of 30 mg/kg of either L-DOPA or 5-hydroxy-L-tryptophan. This capacity limitation was most likely interpreted as different affinity of the striatal aromatic amino acid decarboxylase for L-DOPA and 5-hydroxy-L-tryptophan, respectively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01245006
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    Paper (German National Licenses)
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