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  • 1
    Electronic Resource
    Electronic Resource
    Isolation of clones from T24 cells and test of their sensitivity to adriamycin (1988)
    Springer
    Research in experimental medicine 188 (1988), S. 239-246 
    Details
    ISSN: 1433-8580
    Keywords: T24 ; Heterogeneity ; Single cell clone ; Adriamycin ; Chemosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two single cell clones, CL3 and CL7, were developed from T24 cells. CL3 had abundant cytoplasmic granules, while CL7 did not have as much. CL3 and CL7 exhibited a modal number of chromosomes at 69 and 74, respectively. CL7 had a higher growth rate than CL3, as indicated by in vitro cell growth, plating efficiency, and growth of the tumors produced in nude mice. CL3 was slightly susceptible to adriamycin toxicity as compared to CL7.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01852272
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of prostaglandins and other putative chemical intermediaries on the activity of canine testicular polymodal receptors studied in vitro (1987)
    Springer
    Pflügers Archiv 408 (1987), S. 565-572 
    Details
    ISSN: 1432-2013
    Keywords: Visceral nociceptor ; Hyperalgesia ; Prostaglandins ; 5-Hydroxytryptamine ; Substance P ; Acetylsalicylic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract (1) An in vitro testis-superior spermatic nerve preparation was used to evaluate the effects of chemical agents applied in the bathing solution. Both directly evoked discharges and responses to algesic solutions [bradykinin (BK) 9×10−8 M, hypertonic saline 616 mM and high K+ solution 60 mM] of polymodal receptors were studied. (2) Prostaglandin (PG)-E2 (1.4×10−6–1.4×10−5 M) and serotonin (5-HT) (1.1×10−6 to 1.4×10−4 M) had only a weak excitatory effect. However, test responses to algesic substances were regularly greatly increased by PG-E2,-I2 and 5-HT. Concentrations of PG-E2 of 1.4×10−8 M or grealer augmented BK responses; higher concentrations and/or longer applications were needed to enhance responses to algesic salt solutions. Effective concentrations for the PGs and 5-HT were near those reported for inflamed tissues and exudate. (3) Aspirin (ASA) (5.5×10−4 M or greater, for more than 4 min) suppressed the responses to BK but not those evoked by hypertonic saline. The ASA effect on the BK response was largely restored by an addition of PG-E2. (4) Substance P also had a weak excitatory effect on some polymodal receptors, but no significant enhancement of the response to BK was noted. (5) These results further support a role of polymodal receptors in transmitting nociceptive information, of inflammatory origin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00581157
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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