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  • 1
    Electronic Resource
    Electronic Resource
    Somatostatin and Alzheimer's disease: a hypothesis (1986)
    Springer
    Journal of neurology 233 (1986), S. 370-372 
    Details
    ISSN: 1432-1459
    Keywords: Alzheimer's disease ; Somatostatin ; Endocrine system ; Amyloid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent data suggest a disturbance of some brain somatostatin neurons in Alzheimer's disease. Moreover, some endocrine activities known to be regulated by somatostatin, such as growth hormone, thyroid-stimulating-hormone, somatomedins, as well as insulin and glucose metabolism, also seem to be affected in some patients. It is speculated that these changes are due to a global CNS and endocrine somatostatin defect in Alzheimer's disease and that the described endocrine imbalance may indirectly be responsible for at least part of the CNS pathology.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313925
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of GABA, dopamine, and substance P on the release of newly synthesized 3H-5-hydroxytryptamine from rat substantia nigra in vitro (1978)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 271-275 
    Details
    ISSN: 1432-1912
    Keywords: Substantia nigra ; 5-Hydroxytryptamine ; α-Flupenthixol ; Substance P ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of GABA, substance P and dopamine on the release of newly synthesized 3H-5-HT were investigated, using slices of rat substantia nigra superfused with l-3H-tryptophan in vitro. GABA (50 μM) had no inhibitory effect on the potassium-evoked-release of 3H-5-HT. Substance P (50 μM) and eledoisin (50 μM) stimulated the spontaneous release of 3H-5-HT. This effect seems to be indirect and is possibly mediated by dopaminergic neurones, since the dopamine antagonist drug α-flupenthixol (1 μM) abolished the substance P-evoked release of 5-HT. Furthermore, it was found that substance P (10 μM) stimulated 3H-dopamine release from nigral slices in vitro and the dopaminergic agonist apomorphine (50 μM) also stimulated 3H-5-HT release. Substance P may, therefore, activate nigral dopaminergic neurones which then release dopamine from their dendrites. The release of dopamine may in turn stimulate 5-HT release from terminals of the raphe-nigral pathway.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00507968
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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