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  • 1
    Electronic Resource
    Electronic Resource
    Effects of indorenate on food intake: a comparison with fenfluramine and amphetamine (1995)
    Springer
    Psychopharmacology 117 (1995), S. 91-101 
    Details
    ISSN: 1432-2072
    Keywords: Indorenate ; Food intake ; Fenfluramine ; Anorexia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Indorenate (TR3369, 5-methoxytryptamine b-methylcarboxylate HCl) is a 5-HT1-like receptor agonist with hypotensive activity. Here, we describe that indorenate also decreases food intake (ED50 26.1 mg/kg) without an appreciable effect in water intake (the estimated ED50 for water was 589.8 mg/kg). The anorectic activity of indorenate was compared to the effects of amphetamine and other serotonin agonists; the effect of indorenate was smaller than those of the other compounds; however, the effect of indorenate was specific to food, whereas all the other drugs also produced significant decrements in water intake. The serotonin antagonists cinanserin, cyproheptadine, methergoline and methysergide effectively prevented the decrease in food intake produced by indorenate and fenfluramine. Haloperidol, a dopaminergic antagonist, was ineffective in preventing the effect of indorenate although it prevented the anorectic effect of amphetamine. The present results suggest the participation of serotoninergic, but not dopaminergic mechanisms, in the decrease in food intake produced by indorenate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245103
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  • 2
    Electronic Resource
    Electronic Resource
    The role of the ascending 5-hydroxytryptaminergic pathways in timing behaviour: further observations with the interval bisection task (1995)
    Springer
    Psychopharmacology 120 (1995), S. 213-219 
    Details
    ISSN: 1432-2072
    Keywords: 5-hydroxytryptamine ; 5,7-Dihydroxytryptamine ; Operant behaviour ; Timing ; Interval bisection procedure ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This experiment examined the effect of destroying the 5-hydroxytryptaminergic (5HTergic) pathways on rats' ability to discriminate between two durations. Rats received injections of 5,7-dihydroxytryptamine into the median and dorsal raphe nuclei or sham lesions. They were trained to press lever A following a 2-s presentation of a light and lever B following an 8-s presentation of the light. For some rats, the levers were inserted into the chamber immediately after stimulus presentation (“no-poke-requirement”); for others, the levers were not inserted until a flap covering the food tray positioned midway between the levers had been depressed (“poke-requirement”). When stable performance was attained, “probe” trials were introduced in which the light was presented for intermediate durations. Logistic functions were derived relating percent choice of lever B to log stimulus duration. Under the “no-poke-requirement” condition, the bisection point (duration yielding 50% choice of lever B) was shorter in the lesioned rats than in the control rats. Under the “poke-requirement” condition, this effect of the lesion was attenuated. There was no effect of the lesion on the Weber fraction under either condition. The levels of 5HT and 5-hydroxyindoleacetic acid were reduced in the brains of the lesioned rats, but the levels of noradrenaline and dopamine were not altered. It is proposed that rats may attain accurate timing under the interval bisection task by moving from one lever to the other during stimulus presentation; this movement may be facilitated by destruction of the 5HTergic pathways. Accurate timing is still possible when this movement is suppressed by the introduction of a “poke requirement”; however, in this case timing is not affected by 5HT depletion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02246196
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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