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  • 1
    Electronic Resource
    Electronic Resource
    The production of podophyllotoxin and its 5-methoxy derivative through bioconversion of cyclodextrin-complexed desoxypodophyllotoxin by plant cell cultures (1995)
    Springer
    Plant cell, tissue and organ culture 42 (1995), S. 73-79 
    Details
    ISSN: 1573-5044
    Keywords: Glucosides ; Linum flavum ; 5-methoxypodophyllotoxin ; podophyllotoxin ; Podophyllum hexandrum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The bioconversion of the lignan desoxypodophyllotoxin by cell suspensions of Linum flavum and of Podophyllum hexandrum was investigated. The apolar substrate could be easily dissolved in the culture medium at a concentration of 2 mM by complexation with dimethyl-β-cyclodextrin. Growth parameters of the cell suspensions were not affected by either the addition of cyclodextrin itself, or when cyclodextrin-complexed desoxypodophyllotoxin was present in the medium. The complexed lignan disappeared from the medium within 7 days for both cell cultures. Cellularly only small amounts of desoxypodophyllotoxin were found. After feeding of desoxypodophyllotoxin, the cell culture of L. flavum accumulated 5-methoxypodophyllotoxin and 5-methoxypodophyllotoxin-β-D-glucoside. After 7 days a total maximal content of 2.38% on a dry weight basis of 5-methoxypodophyllotoxin was formed, corresponding with 249 mg l-1 suspension. The highest bioconversion percentage of 52.3% was found at day 14. The desoxypodophyllotoxin-fed culture of P. hexandrum accumulated podophyllotoxin and its β-D-glucoside with a maximal content of 2.87% on a dry weight basis after 9 days, corresponding with 192 mg 1-1 suspension. The highest bioconversion percentage of 33.2% was also found at day 9.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00037684
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Traditional Chinese herbal medicine (1995)
    Springer
    Pharmacy world & science 17 (1995), S. 103-112 
    Details
    ISSN: 1573-739X
    Keywords: Books ; Drug screening ; Drugs, Chinese herbal ; Education ; History of medicine ; Medicine, Chinese traditional ; Pharmacology ; Quality control ; Research
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Herbal medicine, acupuncture and moxibustion, and massage are the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the most important part of traditional Chinese medicine, is less well known in the West. This article gives a brief introduction to the written history, theory, and teaching of Chinese herbal medicine in China. It also describes modern scientific research into and the quality control of Chinese herbal medicines in China. Some examples of how new drugs derived from Chinese herbs have been developed on the basis of traditional therapeutic experience are presented. Finally, the situation of Chinese herbal medicine in the West is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01872386
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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