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  • 6-N-hydroxylaminopurine  (2)
  • Polycystic ovaries  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Prevalence of polycystic ovaries in women with acne (1989)
    Springer
    Archives of dermatological research 281 (1989), S. 502-503 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Acne ; Polycystic ovaries ; Pelvic ultrasound
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The prevalence of polycystic ovaries was determined by pelvic ultrasound imaging in 119 women (mean age, 23.6±6.06 years; range, 14–45 years) with acne but with no menstrual disorders, obesity, or hirsutism, and in 35 healthy controls (mean age, 25±5.8 years; range, 21–40 years). Polycystic ovaries were found in 54 out of 119 patients with acne (45.37%) and in 6 out of 35 controls (17.14%). The results of this study indicate that polycystic ovaries are common in women with acne and not necessarily associated with menstrual disorders, obesity, or hirsutism.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00510088
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Starvation in yeast increases non-adaptive mutation (1999)
    Springer
    Current genetics 35 (1999), S. 77-81 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Key words Adaptive mutations ; 6-N-hydroxylaminopurine ; Saccharomyces cerevisiae
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The frequency of reversion in a histidine-requiring mutant of Saccharomyces cerevisiae increases about ten-fold in stationary cells during histidine starvation. Histidine starvation enhances a similar frequency of reversion in a tryptophan-requiring mutant. Starvation, therefore, enhances mutation frequencies in a non-adaptive manner. The base analogue 6-N-hydroxylaminopurine (HAP) added prior to plating on medium with limited histidine strongly increases reversion of the histidine mutant. HAP-induced reversion increases further in stationary starving cells with the same kinetics as that which increases spontaneous reversion. Adding HAP to the stationary starving cells does not produce any effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002940050435
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    6-N-hydroxylaminopurine (HAP)-induced accumulation of variability in haploid and diploid strains of Aspergillus nidulans (1997)
    Springer
    Current genetics 32 (1997), S. 331-336 
    Details
    ISSN: 1432-0983
    Schlagwort(e): Key wordsAspergillus nidulans ; Accumulated variability ; 6-N-hydroxylaminopurine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Haploid and diploid strains of Aspergillus nidulans have been repeatedly treated with the strong mutagen 6-N-hydroxylaminopurine (HAP) which causes only base substitutions. An enormous amount of variability may be rapidly accumulated in haploid or diploid strains of A. nidulans. In particular, in the diploids the analysis of the results shows that after 12 cycles of treatment the conidia differ from each other for about ten recessive lethals and therefore probably for several hundreds of mutations. The viability of the heterozygous multiply mutant diploids is not appreciably different from that of untreated controls. In the diploid strains the accumulated variability was very high. The treatment of a haploid strain during vegetative growth also caused a strong accumulation of mutations, even though deleterious, because they can be maintained in the heterokaryotic condition.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002940050285
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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